68266-37-5

Upstream product

• 3814-99-1 pentylmagnesium iodide 
• 591-31-1 3-methoxy-benzaldehyde 
• 110-53-2 1-Bromopentane 
• 693-25-4 n-pentylmagnesium bromide 

Downstream Products

• 100863-37-4 1-(3-methoxyphenyl)heptan-1-one 
• 68266-38-6 1-chlor-1-(3'-methoxyphenyl)-hexane 
• 68266-28-4 6,7-di-(3'-hydroxyphenyl)-dodecane 
• 68266-39-7 6,7-di-(3'-methoxyphenyl)-dodecane 
• 101873-66-9 1-(4-heptyl-2-hydroxy-phenyl)-3-methyl-butan-1-one 
• 103151-49-1 3-heptylphenol 
• 106522-92-3 1-heptyl-3-methoxybenzene 
• 132858-49-2 1-(3-hydroxyphenyl)-1-heptanone 
• 106380-12-5 1-(3-hydroxy-phenyl)-heptan-1-ol 
• 106591-04-2 1-(3-methoxyphenyl)heptan-1-ol 
• 102175-05-3 5-Heptyl-2-isopentyl-phenol 
• 108240-88-6 isovaleric acid-(3-heptyl-phenyl ester) 
• 102020-40-6 6-heptyl-2-hydroxy-3-isopentyl-benzaldehyde 
• 110051-83-7 2-heptyl-4-hydroxy-5-isopentyl-isophthalaldehyde 

Relevant academic research and scientific papers

Tandem α-Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols

Tandem α-alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl2]2 in combination with an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated in moderate yields and in moderate to good enantiomeric excess (up to 89 % ee). One catalyst - one pot - two reactions. Acetophenones are initially alkylated with primary alcohols by the borrowing hydrogen methodology. The alkylation products are directly converted to enantiomerically enriched secondary alcohols.

Potential Antiestrogens. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 1,2-Dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes

The syntheses of the meso-1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes and of d,l-3,4-bis(3'-hydroxyphenyl)hexane (21) are described.In vitro these compounds inhibited the estradiol receptor interaction competitively, exhibiting Ka values between 0.20*109 (20) and 0.11*106 M-1 (24).In vivo the meso compounds reduced the estrone-stimulated mouse uterine growth; the most effective compounds were 20, 22, and 23 (53, 50, and 45percent inhibition, respectively).Compounds 20 and 22-24 showed weak estrogenic activity in the mouse uterine weight test and in the vaginal cornification test.Compounds 19 (NSC-297169), 20 (NSC-297170), and 22 (NSC-297171) exhibited a dose-dependent growth inhibition on the MCF-7 human breast tumor cell line (10-6 to 10-9 M).These compounds also showed a marked dose-dependent inhibition on the DMBA-induced, hormone-dependent mammary carcinoma of the Sprague-Dawley rat corresponding to their association constants.

Novel di-(3'-hydroxyphenyl)-alkane compounds, process of preparation and their use in medicine

Compounds of di-(3'-hydroxyphenyl)-alkanes and their methyl ethers, of the formula STR1 wherein R is alkyl and R' is H or methyl, have activity against hormone-dependent breast carcinoma.