10320-59-9

Usage

Uses

Used in Pharmaceutical Research:
6-chloro-1-methylquinazoline-2,4(1H,3H)-dione is utilized as a potential drug candidate for the treatment of various diseases due to its unique chemical structure and potential biological activities. Its specific properties and therapeutic potential are still under investigation, with the aim of identifying its efficacy and safety in treating different medical conditions.
Used in Chemical Synthesis:
In addition to its potential pharmaceutical applications, 6-chloro-1-methylquinazoline-2,4(1H,3H)-dione may also serve as a valuable intermediate in the synthesis of other chemical compounds. Its unique structure and functional groups can be further modified or used as a building block in the development of new molecules with specific properties and applications in various industries.

Upstream product

• 889849-94-9 3-tert-butyl-6-chloro-1-methyl-1H-quinazoline-2,4-dione 
• 55150-07-7 5-chloro-2-methylaminobenzoic acid methyl ester 
• 85-91-6 Methyl N-methylanthranilate 
• 134-20-3 2-carbomethoxyaniline 
• 57-13-6 urea 
• 33280-14-7 5-chloro-2-methylamino-benzoic acid 
• 207735-50-0 3-(tert-butyl)-6-chloroquinazoline-2,4(1H,3H)-dione 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 

Relevant academic research and scientific papers

Acetylhydrazone-based compounds and preparation method thereof

The invention discloses acetylhydrazone-based compounds and a preparation method thereof. The acetylhydrazone-based compounds are 2-(1-methyl-6-chloro-2,4 (1H, 3H)-quinazolinedione) acetylhydrazone-based compounds expressed by a general formula I. In-vitro antimicrobial activity tests find that the acetylhydrazone-based compounds have certain inhibitory activity on gram-positive bacteria (staphylococcus aureus, methicillin-resistant staphylococcus aureus and bacillus subtilis), gram-negative bacteria (escherichia coli, proteusbacillus vulgaris and pseudomonas aeruginosa), and fungi (candida albicans, aspergillus flavus, aspergillus fumigatus and cryptococcus neoformans), and some compounds have the inhibitory activity on some tested strains that is close and even prior to the inhibitory activity of the existing drug streptomycin sulfate polyoxin B, so that the compounds can be used for preparing antibacterial and/or antifungal drugs. The preparation method for the compounds is simple, the raw materials are easily available, and the cost is relatively low.

Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists

Several potent, functionally active MCHr1 antagonists derived from quinolin-2(1H)-ones and quinazoline-2(1H)-ones have been synthesized and evaluated. Pyridylmethyl substitution at the quinolone 1-position results in derivatives with low-nM binding potency and good selectivity with respect to hERG binding.