55150-07-7

Basic information

• Product Name: Methyl 5-chloro-2-(methylamino)benzoate
• Synonyms: Methyl 5-chloro-2-(methylamino)benzoate;methyl N-methyl-5-chloro-anthranilate
• CAS NO: 55150-07-7
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.6342
• Mol File: 55150-07-7.mol

Chemical Properties

• Melting Point: 63-64 °C
• Boiling Point: 307.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.11±0.12(Predicted)
• CAS DataBase Reference: Methyl 5-chloro-2-(methylamino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-chloro-2-(methylamino)benzoate(55150-07-7)
• EPA Substance Registry System: Methyl 5-chloro-2-(methylamino)benzoate(55150-07-7)

Safety Data

• Hazardous Substances Data: 55150-07-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-chloro-2-(methylamino)benzoate is used as a key intermediate in the synthesis of various medications. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications, making it an essential component in the pharmaceutical manufacturing process.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 5-chloro-2-(methylamino)benzoate is utilized as a crucial intermediate in the production of pesticides. Its versatile chemical properties enable the creation of effective pest control agents, contributing to improved crop protection and agricultural productivity.
Overall, Methyl 5-chloro-2-(methylamino)benzoate's diverse applications in both the pharmaceutical and agrochemical industries highlight its significance as a valuable chemical compound, driving innovation and advancements in the development of new products and solutions.

Upstream product

• 635-21-2 5-chloroanthranilic acid 
• 134-20-3 2-carbomethoxyaniline 
• 521064-80-2 5-chloro-2-dimethylaminobenzoic acid methyl ester 

Downstream Products

• 33280-14-7 5-chloro-2-methylamino-benzoic acid 
• 10320-59-9 1-methyl-6-chloroquinazolin-2,4-dione 
• 67447-29-4 2'-N-Methylamino-5'-chloro-2-(phenylsulphonyl)-acetophenone 
• 889849-90-5 5-Chloro-2-[(2-cyano-acetyl)-methyl-amino]-benzoic acid methyl ester 

Relevant articles and documents

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Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed by scaffold hopping. Structure-activity relationship studies led to the discovery of compound 15j, which shows low nanomolar inhibitory activity against the HCT116 cell line. Further antitumor mechanism studies indicated that compound 15j acted by the dual inhibition of topoisomerase 1 and tubulin and induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt of compound 15j (compound 15js) exhibited excellent in vivo antitumor activity (TGI = 66.6%) in the HCT116 xenograft model with low toxicity. Indolopyrazinoquinazolinone derivatives represent promising multitargeting antitumor leads for the development of novel antitumor agents.

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