33280-14-7Relevant academic research and scientific papers
Acetylhydrazone-based compounds and preparation method thereof
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Paragraph 0072; 0079; 0080; 0081, (2017/08/25)
The invention discloses acetylhydrazone-based compounds and a preparation method thereof. The acetylhydrazone-based compounds are 2-(1-methyl-6-chloro-2,4 (1H, 3H)-quinazolinedione) acetylhydrazone-based compounds expressed by a general formula I. In-vitro antimicrobial activity tests find that the acetylhydrazone-based compounds have certain inhibitory activity on gram-positive bacteria (staphylococcus aureus, methicillin-resistant staphylococcus aureus and bacillus subtilis), gram-negative bacteria (escherichia coli, proteusbacillus vulgaris and pseudomonas aeruginosa), and fungi (candida albicans, aspergillus flavus, aspergillus fumigatus and cryptococcus neoformans), and some compounds have the inhibitory activity on some tested strains that is close and even prior to the inhibitory activity of the existing drug streptomycin sulfate polyoxin B, so that the compounds can be used for preparing antibacterial and/or antifungal drugs. The preparation method for the compounds is simple, the raw materials are easily available, and the cost is relatively low.
Synthesis of 1-substituted 4(1H)-quinazolinones under solvent-free conditions
Wang, Yao,Zhang, Mei,Cao, Shengli,Lin, Huihui,Gao, Man,Li, Zhongfeng
, p. 2715 - 2727 (2012/07/14)
(Chemical Equation Presented) Heating a mixture of 2-(N-alkylamino)benzoic acids, triethyl orthoformate, and ammonium acetate under solvent-free conditions generated 1-substituted 4(1H)- quinazolinones in 73-99% yields. Moreover, a possible reaction pathway was proposed. Copyright Taylor & Francis Group, LLC.
Efficient copper-catalyzed synthesis of N-alkylanthranilic acids via an ortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature
Zeng, Liang,Fu, Hua,Qiao, Renzhong,Jiang, Yuyang,Zhao, Yufen
supporting information; experimental part, p. 1671 - 1676 (2011/02/25)
We have developed an efficient copper-catalyzed method for the synthesis of N-alkylanthranilic acids. The protocol uses inexpensive copper(I) iodide/racemic 1,1'-binaphthyl-2,2'-diol (rac-BINOL) as the catalyst/ligand system, readily available 2-halobenzoic acids and aliphatic amines as the starting materials, the coupling reactions were performed at room temperature, and various functionalities in the substrates were tolerated.
Heteroaryl and benzyl amide compounds
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Page/Page column 17, (2008/06/13)
Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
New Synthesis of Diazepam
Gates, Marshall
, p. 1675 - 1681 (2007/10/02)
An efficient preparation of 7-chloro-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione from 5-chloro-N-methylisatoic anhydride and glycine has been devised, and from it, by the action of phenylmagnesium chloride on its N-acetyl-derivative followed by treatment with hydroxylamine and cleavage of the resulting desacetyl oxime with sodium bisulfite, diazepam has been synthesized.The overall yield is about 50percent from 5-chloroisatoic anhydride.
The Chemistry of 2H-1,3-Benzoxazine-2,4-(1H)dione (Isatoic Anhydride). 8. A One Step Synthesis of the Quinindoline Ring System and Related Compounds
Coppola, Gary M.
, p. 1785 - 1787 (2007/10/02)
The reaction between N-substituted isatoic anhydrides and the carbanion generated from 3-methylthiooxindole to produce the quinindoline ring skeleton is discussed.Analogous reactions of azaisatoic anhydride 6 and tricyclic anhydride 8 produces the 4-aza analog 7 and pentacycle 9.Some spectral data is also described.
