33280-14-7

Basic information

• Product Name: 5-chloro-2-(methylamino)benzoic acid
• Synonyms: 5-Chloro-2-(methylamino)benzoic acid; benzoic acid, 5-chloro-2-(methylamino)-
• CAS NO: 33280-14-7
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.6076
• Mol File: 33280-14-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 357.73°C at 760 mmHg
• Flash Point: 170.15°C
• Density: 1.392g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 5-chloro-2-(methylamino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(methylamino)benzoic acid(33280-14-7)
• EPA Substance Registry System: 5-chloro-2-(methylamino)benzoic acid(33280-14-7)

Safety Data

• Hazardous Substances Data: 33280-14-7(Hazardous Substances Data)

Upstream product

• 55150-07-7 5-chloro-2-methylaminobenzoic acid methyl ester 
• 85-91-6 Methyl N-methylanthranilate 
• 134-20-3 2-carbomethoxyaniline 
• 3484-33-1 2-(methylamino)-5-nitrobenzoic acid 
• 119-68-6 N-Methylanthranilic acid 
• 4743-17-3 5-Chloroisatoic anhydride 
• 14529-12-5 6-chloro-N-methylisatoic anhydride 
• 56-40-6 glycine 
• 40800-64-4 3-methylsulfanyl-1,3-dihydroindol-2-one 
• 17630-76-1 5-chloroindole 2,3-dione 
• 60434-13-1 5-chloro-1-methylindoline-2, 3-dione 
• 21739-93-5 2-bromo-5-chlorobenzoic acid 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 10320-59-9 1-methyl-6-chloroquinazolin-2,4-dione 

Relevant articles and documents

Acetylhydrazone-based compounds and preparation method thereof

The invention discloses acetylhydrazone-based compounds and a preparation method thereof. The acetylhydrazone-based compounds are 2-(1-methyl-6-chloro-2,4 (1H, 3H)-quinazolinedione) acetylhydrazone-based compounds expressed by a general formula I. In-vitro antimicrobial activity tests find that the acetylhydrazone-based compounds have certain inhibitory activity on gram-positive bacteria (staphylococcus aureus, methicillin-resistant staphylococcus aureus and bacillus subtilis), gram-negative bacteria (escherichia coli, proteusbacillus vulgaris and pseudomonas aeruginosa), and fungi (candida albicans, aspergillus flavus, aspergillus fumigatus and cryptococcus neoformans), and some compounds have the inhibitory activity on some tested strains that is close and even prior to the inhibitory activity of the existing drug streptomycin sulfate polyoxin B, so that the compounds can be used for preparing antibacterial and/or antifungal drugs. The preparation method for the compounds is simple, the raw materials are easily available, and the cost is relatively low.

Efficient copper-catalyzed synthesis of N-alkylanthranilic acids via an ortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature

We have developed an efficient copper-catalyzed method for the synthesis of N-alkylanthranilic acids. The protocol uses inexpensive copper(I) iodide/racemic 1,1'-binaphthyl-2,2'-diol (rac-BINOL) as the catalyst/ligand system, readily available 2-halobenzoic acids and aliphatic amines as the starting materials, the coupling reactions were performed at room temperature, and various functionalities in the substrates were tolerated.

New Synthesis of Diazepam

An efficient preparation of 7-chloro-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione from 5-chloro-N-methylisatoic anhydride and glycine has been devised, and from it, by the action of phenylmagnesium chloride on its N-acetyl-derivative followed by treatment with hydroxylamine and cleavage of the resulting desacetyl oxime with sodium bisulfite, diazepam has been synthesized.The overall yield is about 50percent from 5-chloroisatoic anhydride.