1032174-10-9

Basic information

• Product Name: 1-(4-methoxy-3-nitrophenyl)-butan-1-one
• Synonyms: 1-(4-methoxy-3-nitrophenyl)-butan-1-one
• CAS NO: 1032174-10-9
• Molecular Weight: 223.229
• Mol File: 1032174-10-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxy-3-nitrophenyl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxy-3-nitrophenyl)-butan-1-one(1032174-10-9)
• EPA Substance Registry System: 1-(4-methoxy-3-nitrophenyl)-butan-1-one(1032174-10-9)

Safety Data

• Hazardous Substances Data: 1032174-10-9(Hazardous Substances Data)

Upstream product

• 4160-51-4 1-(4-methoxyphenyl)-1-butanone 
• 100-66-3 methoxybenzene 
• 91-23-6 2-Nitroanisole 
• 141-75-3 butyryl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 22135-50-8 1-(4-(methoxy)phenyl)butan-1-ol 

Downstream Products

• 1032174-26-7 4-ethyl-3-(4-methoxy-3-nitrophenyl)-1,5-bis-(4-methoxyphenyl)-1H-pyrazole 

Relevant articles and documents

Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments

To realize PDE4 inhibitors with good developmental potentiality for the treatment of dementia, structure-based optimizations of lead compound FCPR03 resulted in novel aminophenylketones 9c and 9H with low nanomolar potency, which displayed comparable acti

Aminophenone compounds as well as preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to aminophenone compounds as well as a preparation method and application thereof. The aminophenone compounds provided by the invention have a good inhibition effect on PDE4, also have good bioavailability, can be applied to preparation of drugs for treating PDE4-related diseases, and increase the optionsof drugs for treating PDE4-related diseases; and the effect of a part of the aminophenone compounds is equivalent to the effect of positive drugs, and the aminophenone compounds have good developmentpotential.

Synthesis and characterization of AlCl3 impregnated molybdenum oxide as heterogeneous nano-catalyst for the Friedel-Crafts acylation reaction in ambient condition

Aluminum trichloride (AlCl3) impregnated molybdenum oxide heterogeneous nano-catalyst was prepared by using simple impregnation method. The prepared heterogeneous catalyst was characterized by powder X-ray diffraction, FT-IR spectroscopy, solid-state NMR spectroscopy, SEM imaging, and EDX mapping. The catalytic activity of this protocol was evaluated as heterogeneous catalyst for the Friedel-Crafts acylation reaction at room temperature. The impregnated MoO4(AlCl2)2 catalyst showed tremendous catalytic activity in Friedel-Crafts acylation reaction under solvent-free and mild reaction condition. As a result, 84.0% yield of acyl product with 100% consumption of reactants in 18 h reaction time at room temperature was achieved. The effects of different solvents system with MoO4(AlCl2)2 catalyst in acylation reaction was also investigated. By using optimized reaction condition various acylated derivatives were prepared. In addition, the catalyst was separated by simple filtration process after the reaction and reused several times. Therefore, heterogeneous MoO4(AlCl2)2 catalyst was found environmentally benign catalyst, very convenient, high yielding, and clean method for the Friedel-Crafts acylation reaction under solvent-free and ambient reaction condition.

Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands

Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities.