1032429-79-0Relevant articles and documents
A Recyclable Chiral 2-(Triphenylmethyl)pyrrolidine Organocatalyst Anchored to [60]Fullerene
Rosso, Cristian,Emma, Marco G.,Martinelli, Ada,Lombardo, Marco,Quintavalla, Arianna,Trombini, Claudio,Syrgiannis, Zois,Prato, Maurizio
, p. 2936 - 2944 (2019/04/26)
Hybridization of a chiral 3-hydroxy-2-trityl-pyrrolidine deriving from (R)-pyrrolidinol with [60]fullerene via click chemistry provides a highly efficient supported enantioselective organocatalyst, which was successfully exploited in a Michael addition of
Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis
?tv?s, Sándor B.,Pericàs, Miquel A.,Kappe, C. Oliver
, p. 11141 - 11146 (2019/12/28)
The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant (-)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The critical step is a solvent-free organocatalytic conjugate addition followed
Highly enantioselective and recyclable organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in aqueous media
Ghosh, Subrata K.,Dhungana, Kritanjali,Headley, Allan D.,Ni, Bukuo
, p. 8322 - 8325 (2012/11/07)
A new type of pyrrolidine-based organocatalyst, which was developed earlier in our lab, has been found to be very effective for the Michael addition reaction in aqueous solvents involving a wide range of α,β- unsaturated aldehydes and malonate derivatives
Ionic polymer-supported O-trimethylsilyl-α,α-diphenyl-(S)- prolinols as recoverable organocatalysts for the asymmetric Michael reactions of carbon acids with α,β-enals
Maltsev, Oleg V.,Kucherenko, Alexander S.,Zlotin, Sergei G.
experimental part, p. 146 - 148 (2011/12/22)
A recyclable organocatalyst bearing O-trimethylsilyl-α,α- diphenyl-(S)-prolinol unit tagged to the imidazolium cation and poly(4-styrenesulfonate) anion in the reaction of CH-acids with α,β-enals provided the respective Michael adducts in high yields (up
Enantioselective michael addition of malonates to aromatic α,β-unsaturated aldehydes organocatalyzed by (s)-2-[bis(3,4,5- trifluorophenyl) trimethylsilanyloxymethyl]pyrrolidine
Ye, Haiwei,Zheng, Yemin,Yu, Chuanming,Zhong, Weihui
experimental part, p. 520 - 525 (2012/04/11)
The Michael addition of malonates to aromatic α,β-unsaturated aldehydes was efficiently organocatalyzed by (S)-2-[bis(3,4,5-trifluorophenyl) trimethylsilanyoxymethyl]pyrrolidine, derived from L-proline to afford the corresponding adducts in good yields wi
Diastereoselective syntheses of indoloquinolizidines by a pictet-spengler/lactamization cascade
Fang, Huihui,Wu, Xiaoyu,Nie, Linlin,Dai, Xiaoyang,Chen, Jie,Cao, Weiguo,Zhao, Gang
supporting information; experimental part, p. 5366 - 5369 (2011/03/19)
An expedient diastereoselective synthesis of highly functionalized indolo[2,3-α]quinolizidines adopting a cis H2/H12b geometry has been realized by a Pictet-Spengler/lactamization cascade sequence. The absolute stereochemistry at C2, C3, and C12b was gove
O-TMS-α,α-diphenyl-(S)-prolinol modified with an ionic liquid moiety: A recoverable organocatalyst for the asymmetric michael reaction between α,β-enals and dialkyl malonates
Maltsev, Oleg V.,Kucherenko, Alexandr S.,Zlotin, Sergei G.
supporting information; experimental part, p. 5134 - 5137 (2010/01/03)
O-TMS-α,β-diphenyl-(S)-prolinol derivative bearing an ionic liquid fragment was synthesized for the first time and proven to be an efficient catalyst for the asymmetric Michael reaction of aromaticα,β- unsaturated aldehydes with dialkyl malonates. The pre
Enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in water
Ma, Anqi,Zhu, Shaolin,Ma, Dawei
, p. 3075 - 3077 (2008/09/20)
The Michael addition of malonates to α,β-unsaturated aldehydes catalyzed by O-TMS protected diphenylprolinols and acetic acid in water occurs at 0 °C to rt. In most cases, the reaction runs to completion in less than 24 h. A wide range of aldehydes includ
