216690-18-5

Basic information

• Product Name: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester
• Synonyms: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester
• CAS NO: 216690-18-5
• Molecular Weight: 341.382
• Mol File: 216690-18-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester(216690-18-5)
• EPA Substance Registry System: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester(216690-18-5)

Safety Data

• Hazardous Substances Data: 216690-18-5(Hazardous Substances Data)

Upstream product

• 1032429-79-0 (R)-dimethyl 2-(1-(4-fluorophenyl)-2-formylethyl)malonate 
• 100-46-9 benzylamine 
• 51791-26-5 3-(4-fluoro-phenyl)-propenal 
• 108-59-8 malonic acid dimethyl ester 
• 933775-24-7 (R)-3-benzyl-6-(4-fluorophenyl)[1,2,3]oxathiazinane-2,2-dioxide 

Downstream Products

• 1142923-33-8 C₁₉H₂₀FNO₂ 
• 201855-60-9 (3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanol 
• 105813-14-7 (3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine 
• 201855-71-2 Methanesulfonic acid (3S,4R)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl ester 
• 61869-08-7 paroxetine 

Relevant articles and documents

Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis

The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant (-)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The critical step is a solvent-free organocatalytic conjugate addition followed

Catalytic Asymmetric Hydrogenation of Tetrasubstituted Unsaturated Lactams: An Efficient Approach to Enantioenriched 3,4-Disubstituted Piperidines

Asymmetric hydrogenation of tetrasubstituted alkenes remains a formidable challenge in asymmetric catalysis. We report herein an unprecedented Rh-catalyzed enantioselective and diastereoselective hydrogenation of easily accessed α,β-disubstituted unsaturated lactams to afford synthetically valuable chiral lactams with 1,2-consecutive stereocenters. The reaction could be performed on the gram scale, and the products could be concisely transformed to enantiomerically pure trans-3,4-disubstituted piperidines, which are prevalent structural units in medicinal agents.

Enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in water

The Michael addition of malonates to α,β-unsaturated aldehydes catalyzed by O-TMS protected diphenylprolinols and acetic acid in water occurs at 0 °C to rt. In most cases, the reaction runs to completion in less than 24 h. A wide range of aldehydes includ

Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin

Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates. The Royal Society of Chemistry.