1033-68-7

Basic information

• Product Name: 1-Phenethyl-4-phenylpiperazine
• Synonyms: 1-Phenethyl-4-phenylpiperazine
• CAS NO: 1033-68-7
• Molecular Formula: C₁₈H₂₂N₂
• Molecular Weight: 266.3807
• Mol File: 1033-68-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 77-78 °C
• Boiling Point: 397°Cat760mmHg
• Flash Point: 177.5°C
• Appearance: /
• Density: 1.061g/cm³
• Vapor Pressure: 1.63E-06mmHg at 25°C
• Refractive Index: 1.582
• PKA: 7.51±0.10(Predicted)
• CAS DataBase Reference: 1-Phenethyl-4-phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenethyl-4-phenylpiperazine(1033-68-7)
• EPA Substance Registry System: 1-Phenethyl-4-phenylpiperazine(1033-68-7)

Safety Data

• Hazardous Substances Data: 1033-68-7(Hazardous Substances Data)

Usage

General Description

1-Phenethyl-4-phenylpiperazine is a chemical compound that belongs to the class of piperazines, which are often used in the pharmaceutical industry. It is a psychoactive drug that acts as a stimulant and has been studied for its potential use in treating depression and anxiety. 1-Phenethyl-4-phenylpiperazine has also been identified as a designer drug and has been found in some illicit substances. It is known to have a similar structure to other psychoactive compounds and may have similar effects on the central nervous system, although its specific mechanisms of action are not fully understood. 1-Phenethyl-4-phenylpiperazine is considered a controlled substance in some countries due to its potential for abuse and its psychoactive effects. Research on this compound continues to explore its potential therapeutic uses and its potential risks to public health.

InChI:InChI=1/C18H22N2/c1-3-7-17(8-4-1)11-12-19-13-15-20(16-14-19)18-9-5-2-6-10-18/h1-10H,11-16H2

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 103-63-9 1-phenyl-2-bromoethane 
• 100-42-5 styrene 
• 60-12-8 2-phenylethanol 
• 20020-27-3 2-phenylethyl mesylate 
• 50-00-0 formaldehyd 
• 62673-31-8 benzyl(bromo)zinc 
• 622-24-2 2-phenylethyl chloride 

Relevant articles and documents

Ru-catalyzed β-selective and enantioselective addition of amines to styrenes initiated by direct arene-exchange

A catalytic β-selective addition of amines to styrenes proceeded in the presence of cationic Ru complexes combined with diphosphine ligands. In the reaction of α-methylstyrene, an enantioselective addition was achieved by using xylylBINAP.

Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines

Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes.

RUTHENIUM-CATALYZED HYDROAMINATION OF OLEFINS

Applicants have unexpectedly discovered that catalysts made from a ruthenium catalyst precursor or preformed ruthenium catalysts as otherwise described in the present specification are capable of effecting the addition of a N-H bond across an olefin C=C (olefinic) bond of a substrate with a high degree of regioselectivity and enantioselectivity in high yield. These addition reactions proceed in an anti-Markovnikov or Markovnikov fashion depending upon the catalyst precursor used to generate the ruthenium catalyst which actually participates in the addition reaction. The present invention relates to methods of adding N-H bonds across an olefinic bond in a substrate, using a ruthenium catalyst precursor or catalyst I comprising a compound according to the general structure I: Formula (I) where Ru is a ruthenium atom; L1 represents one or more coordinated ancillary ligands, which may be all the same ligand or which may be a combination of different ligands, each of which may be neutral or formally charged, and each of which may be monodentate and coordinated to ruthenium through a single atom or which may be linked or chelated and bound through more than one atom; L2 represents one or more formally charged ligands which are the same or different and which are optionally susceptible to removal with a strong acid; and x is 0-6, preferably 1, y is 0-6, preferably 2 and n is 1-4, preferably 1.