1033125-49-3

Basic information

• Product Name: 2-(4-dimethoxymethylphenyl)pyridine
• Synonyms: 2-(4-dimethoxymethylphenyl)pyridine
• CAS NO: 1033125-49-3
• Molecular Weight: 229.279
• Mol File: 1033125-49-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-dimethoxymethylphenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-dimethoxymethylphenyl)pyridine(1033125-49-3)
• EPA Substance Registry System: 2-(4-dimethoxymethylphenyl)pyridine(1033125-49-3)

Safety Data

• Hazardous Substances Data: 1033125-49-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 4467-06-5 2-(4-methylphenyl)pyridine 
• 109-04-6 2-bromo-pyridine 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 127406-56-8 4-(2'-pyridyl)benzaldehyde 
• 149-73-5 trimethyl orthoformate 
• 21970-13-8 (pyridin-2-yl)magnesium bromide 

Downstream Products

• 1033125-57-3 2-chloro-6-(4-dimethoxymethylphenyl)pyridine 
• 198904-31-3 atazanavir 
• 127406-56-8 4-(2'-pyridyl)benzaldehyde 
• 1292296-09-3 1-[4-(pyridin-2-yl)phenyl]-2,5-bis{[N-(methoxycarbonyl)-L-tert-leucinyl]amino}-4(S)-hydroxy-6-phenyl-2-azahexane 

Relevant articles and documents

Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes

A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.

Practical routes to 2,6-disubstituted pyridine derivatives

We report the synthesis of a series of 2,6-disubstituted pyridines in a straightforward manner starting from readily available 2-substituted pyridines. The main sequence involves a selective ?-lithiation reaction with halogen functionalization followed by

PROCESS FOR THE PREPARATION OF ARYL-PIRIDYL COMPOUNDS

A method is described for the preparation of aryl-pyridine compounds of formula (I) by cross-coupling reaction, promoted by catalytic systems based on palladium or nickel between compounds of formula (II) and (III) in which: - Met represents Mg or Zn, - Y represents C1, Br, I or acetoxy, - Z represents I, Br, Cl, triflate, sulphonate, phosphate, - Rl, R2, R3, R4, which are the same as one another or different, represent hydrogen, a linear and/or branched Cl-C4 alkyl, and/or an aryl, and/or a heteroaryl, or Rl and R2 and/or R3and R4, taken together, form a C3-C8 ring, an aryl and/or a heteroaryl, - A represents -COR5 where R5 represents hydrogen, a linear and/or branched Cl-C4 alkyl, and/or an aryl, and/or a heteroaryl, or - A represents -CRs5(OR6)(OR7) where R5 has the meaning described above and R6 and R7, which are the same as one another or different, represent a linear and/or branched C1-C4 alkyl, and/or an aryl, and/or a heteroaryl, or R6 and R7, joined together, represent a C1-C8 alkyl or alkenyl.