1033202-51-5

Basic information

• Product Name: 2-cyano-3-nitro-5-fluoropyridine
• Synonyms: 2-cyano-3-nitro-5-fluoropyridine;5-fluoro-3-nitropyridine-2-carbonitrile;2-CYANO-5-FLUORO-3-NITROPYRIDINE;5-FLUORO-3-NITROPICOLINONITRILE
• CAS NO: 1033202-51-5
• Molecular Formula: C6H2FN3O2
• Molecular Weight: 167
• Product Categories: Heterocyclic Compounds
• Mol File: 1033202-51-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 328.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -6.78±0.20(Predicted)
• CAS DataBase Reference: 2-cyano-3-nitro-5-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-3-nitro-5-fluoropyridine(1033202-51-5)
• EPA Substance Registry System: 2-cyano-3-nitro-5-fluoropyridine(1033202-51-5)

Safety Data

• Hazardous Substances Data: 1033202-51-5(Hazardous Substances Data)

Usage

General Description

2-Cyano-3-nitro-5-fluoropyridine is a chemical compound with the molecular formula C6H3N3O2F. It is a yellow solid with a molecular weight of 165.1 g/mol. 2-Cyano-3-nitro-5-fluoropyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known for its potential use in the treatment of various diseases and as a building block in the development of new drugs. 2-Cyano-3-nitro-5-fluoropyridine is also used as a reagent in organic synthesis and as a precursor in the production of other chemicals. However, it is important to handle this chemical with caution as it may present health and environmental hazards.

Upstream product

• 652160-72-0 2-bromo-5-fluoro-3-nitropyridine 

Downstream Products

• 1065267-14-2 (3,5-difluoro-pyridin-2-yl)-methanol 
• 955885-64-0 methyl 3,5-difluoropyridine-2-carboxylate 
• 1620011-82-6 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide 
• 1620011-83-7 3-({[3-amino-6-(2,6-difluorophenyl)-5-fluoropyridin-2-yl]carbonyl}amino)-4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620011-34-8 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide 
• 1052714-16-5 3-amino-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylic acid 
• 1052714-18-7 3-amino-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxylicacidmethylester 
• 1052714-13-2 3-amino-6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester 
• 1620013-06-0 C₃₀H₃₃F₃N₆O₄ 

Relevant articles and documents

CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula (I), independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and 15 deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.