955885-64-0

Basic information

• Product Name: METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE
• Synonyms: METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE;5-difluoropyridine-2-carboxylate;Methyl 3,5-difluoropicolinate, 3,5-Difluoro-2-(methoxycarbonyl)pyridine;Methyl 3,5-difluoropicolinate
• CAS NO: 955885-64-0
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.12
• Mol File: 955885-64-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 211.4°C at 760 mmHg
• Flash Point: 81.7°C
• Appearance: /
• Density: 1.342g/cm³
• Vapor Pressure: 0.182mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.20±0.10(Predicted)
• CAS DataBase Reference: METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE(955885-64-0)
• EPA Substance Registry System: METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE(955885-64-0)

Safety Data

• Hazardous Substances Data: 955885-64-0(Hazardous Substances Data)

Usage

General Description

Methyl 3,5-difluoropyridine-2-carboxylate is a chemical compound with the molecular formula C7H5F2NO2. It is a derivative of pyridine, containing two fluorine atoms and a carboxylate functional group attached to the second carbon atom. METHYL 3,5-DIFLUOROPYRIDINE-2-CARBOXYLATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use in the development of new materials and as a building block in organic synthesis. Methyl 3,5-difluoropyridine-2-carboxylate is known for its strong odor and should be handled with caution due to its potential irritant properties.

InChI:InChI=1/C7H5F2NO2/c1-12-7(11)6-5(9)2-4(8)3-10-6/h2-3H,1H3

Upstream product

• 1033202-51-5 5-fluoro-3-nitropyridine-2-carbonitrile 
• 1052714-11-0 3-amino-5-fluoropyridine-2-carboxylic acid methyl ester 
• 1374115-60-2 3-amino-5-fluoropicolinonitrile 
• 745784-04-7 3,5-difluoropyridine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 

Downstream Products

• 1222633-85-3 2-(chloromethyl)-3,5-difluoropyridine 
• 1065267-14-2 (3,5-difluoro-pyridin-2-yl)-methanol 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS

Provided are compounds of formula (I), or pharmaceutically acceptable salts thereof, which can be used for inhibiting the activity of Aurora A and treating cancer mediated by Aurora A.

Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2-, and -L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

PIPERIDINE DERIVATIVES OR SALTS THEREOF

[Problem] To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism. [Means for Resolution] It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).