1033418-57-3

Basic information

• Product Name: Benzyl 5-methylpyrazin-2-ylcarbamate, 2-(Benzyloxycarbonylamino)-5-methylpyrazine
• Synonyms: 2-(Cbz-Amino)-5-methylpyrazine;Benzyl 5-methylpyrazin-2-ylcarbamate, 2-(Benzyloxycarbonylamino)-5-methylpyrazine
• CAS NO: 1033418-57-3
• Molecular Formula: C₁₃H₁₃N₃O₂
• Molecular Weight: 243.26
• Mol File: 1033418-57-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzyl 5-methylpyrazin-2-ylcarbamate, 2-(Benzyloxycarbonylamino)-5-methylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 5-methylpyrazin-2-ylcarbamate, 2-(Benzyloxycarbonylamino)-5-methylpyrazine(1033418-57-3)
• EPA Substance Registry System: Benzyl 5-methylpyrazin-2-ylcarbamate, 2-(Benzyloxycarbonylamino)-5-methylpyrazine(1033418-57-3)

Safety Data

• Hazardous Substances Data: 1033418-57-3(Hazardous Substances Data)

Usage

General Description

Benzyl 5-methylpyrazin-2-ylcarbamate and 2-(Benzyloxycarbonylamino)-5-methylpyrazine are both organic chemicals that contain a benzene ring and a pyrazine ring. Benzyl 5-methylpyrazin-2-ylcarbamate is a carbamate derivative that is used in the synthesis of various pharmaceutical compounds, while 2-(Benzyloxycarbonylamino)-5-methylpyrazine is a protected form of 5-methylpyrazine that is commonly used in the preparation of peptide and amide compounds. Both of these chemicals are important building blocks in organic synthesis, and they have diverse applications in the pharmaceutical and chemical industries.

Upstream product

• 5521-55-1 2-methylpyrazin-5-carboxylic acid 
• 4129-17-3 diphenylphosphoranyl azide 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 457098-83-8 5-methyl-pyrazine-2-carbonyl azide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 5521-58-4 5-methylpyrazin-2-amine 

Relevant articles and documents

Use of a Curtius Rearrangement as Part of the Multikilogram Manufacture of a Pyrazine Building Block

Commercial route definition for a glucokinase activator called for a reevaluation of the synthesis and processes used to access multikilogram quantities of 2-amino-5-methylpyrazine. After consideration of different options, a variation of the Curtius rearrangement used by the medicinal chemistry route was selected for further development. The formation of an acyl azide for the Curtius rearrangement required a process safety control strategy to be put in place. The process developed was used to successfully deliver multikilogram quantities of 2-amino-5-methylpyrazine in an overall yield of 68%, starting from 5-methylpyrazine-2-carboxylic acid.

CRYSTALLINE POLYMORPHIC FORM 631

A new polymorphic form of 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide, processes for making it and its use as an activator of glucokinase are described.