1033805-22-9

Basic information

• Product Name: LX-1606 Hippurate
• Synonyms: LX-1606 Hippurate;LX 1606;L-Phenylalanine, 4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyriMidinyl]-, ethyl ester, LX-1606;Telotristat ethyl;(S)-ethyl 2-aMino-3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)propanoate 2-benzaMidoacetate;(2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid ethyl ester;LX-1032;(S)-2-amino-3-[4-(2-amino-6-{R-1-[4-chloro-2-(3-methyl-pyrazol-1-yl)-phenyl]-2,2,2-trifluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid ethyl ester
• CAS NO: 1033805-22-9
• Molecular Formula: C₂₇H₂₆ClF₃N₆O₃
• Molecular Weight: 752.1387296
• Mol File: 1033805-22-9.mol

Chemical Properties

• Boiling Point: 704.7±70.0 °C(Predicted)
• Appearance: /
• Density: 1.42
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 6.72±0.33(Predicted)
• CAS DataBase Reference: LX-1606 Hippurate(CAS DataBase Reference)
• NIST Chemistry Reference: LX-1606 Hippurate(1033805-22-9)
• EPA Substance Registry System: LX-1606 Hippurate(1033805-22-9)

Safety Data

• Hazardous Substances Data: 1033805-22-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
LX-1606 Hippurate is used as a predictive marker for serotonin pharmacodynamics and disease-induced dysregulation. This allows researchers to study the biosynthesis of serotonin and its role in various diseases and conditions.
Used in Biological Studies:
In biological studies, LX-1606 Hippurate serves as a valuable tool for understanding the regulation of serotonin levels and its impact on various physiological processes. This can help in the development of targeted therapies and interventions for conditions related to serotonin dysregulation.

Upstream product

• 67-56-1 methanol 
• 1033805-28-5 (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid 
• 64-17-5 ethanol 
• 1125828-44-5 (S)-ethyl 3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoate 
• 1137608-69-5 (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate, hippurate salt 

Downstream Products

• 1137608-69-5 (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate, hippurate salt 
• 1033805-28-5 (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid 

Relevant articles and documents

Based on 4 - phenyl -6 - (2, 2, 2 - trifluoro -1 - phenyl ethoxy) pyrimidine compound and its application method

The present invention relates to compounds based on 4-phenyl-6-(2,2,2-trifluoro-1-phenyl ethoxy) pyrimidine and an application method thereof, particularly discloses compounds of formula I and compositions comprising the compounds, and the application method thereof in treatment, prevention and / or management of diseases or disorders.

SOLID FORMS OF (S)-ETHYL 2-AMINO-3-(4-(2-AMINO-6-((R)-1-(4-CHLORO-2-(3-METHYL-1H-PYRAZOL-1-YL)PHENYL)-2,2,2-TRIFLUOROETHOXY)-PYRIMIDIN-4-YL)PHENYL)PROPANOATE AND METHODS OF THEIR USE

Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate and salts thereof are disclosed.

METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS

Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.

4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS AND METHODS OF THEIR USE

Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: