10340-77-9

Basic information

• Product Name: 2,4,5-TRIMETHYLBENZYL CHLORIDE
• Synonyms: 2,4,5-TRIMETHYLBENZYL CHLORIDE
• CAS NO: 10340-77-9
• Molecular Formula: C₁₀H₁₃Cl
• Molecular Weight: 168.66
• Mol File: 10340-77-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 98-108 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.016±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,4,5-TRIMETHYLBENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIMETHYLBENZYL CHLORIDE(10340-77-9)
• EPA Substance Registry System: 2,4,5-TRIMETHYLBENZYL CHLORIDE(10340-77-9)

Safety Data

• Hazardous Substances Data: 10340-77-9(Hazardous Substances Data)

Usage

Physical state

Liquid

Color

Colorless to pale yellow

Odor

Pungent

Usage

Chemical intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds

Classification

Chlorinated benzyl compound

Reagent

Used in organic synthesis for the preparation of diverse chemical products

Potential applications

Antimicrobial and antiseptic agent

Importance

Essential role in chemical manufacturing and versatile building block for producing a range of valuable products

InChI:InChI=1S/C10H13Cl/c1-7-4-9(3)10(6-11)5-8(7)2/h4-5H,6H2,1-3H3

Upstream product

• 95-63-6 1,2,4-Trimethylbenzene 
• 107-30-2 chloromethyl methyl ether 
• 95-93-2 1,2,4,5-tetramethylbenzene 
• 4393-05-9 2,4,5-trimethyl-benzyl alcohol 
• 50-00-0 formaldehyd 
• 824-55-5 2,4-dimethyl-benzyl chloride 
• 106-42-3 para-xylene 
• 5779-72-6 2,4,5-trimethylbenzaldehyde 
• 18543-92-5 acetic acid 2,4,5-trimethyl-benzyl ester 
• 108-38-3 m-xylene 
• 824-45-3 2,5-dimethylbenzyl chloride 
• 7647-01-0 hydrogenchloride 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 

Downstream Products

• 39502-80-2 2,2',4,5,5'-pentamethyldiphenylmethane 
• 33642-04-5 Bis-(3,6-Dibromo-2,4,5-trimethylbenzyl)ether 
• 33642-00-1 Bis-(3,6-Dichloro-2,4,5-trimethylbenzyl)ether 
• 19405-92-6 3,6-Dibromo-2,4,5-trimethylbenzylnitrate 
• 33641-99-5 3,6-Dichloro-2,4,5-trimethylbenzylnitrat 
• 33642-01-2 (2,5-dibromo-3,4,6-trimethylphenyl)methanol 
• 33641-97-3 3,6-Dichloro-2,4,5-trimethylbenzylalkohol 
• 855195-89-0 2,4,5,2',4',5'-Hexamethyl-benzoin 
• 544697-03-2 (2,4,5-trimethyl-3,6-dinitro-phenyl)-acetic acid 
• 3167-01-9 (2,4,5-trimethyl-phenyl)-acetic acid 
• 30389-88-9 Bis-(2-chlor-aethyl)-(2,4,5-trimethyl-benzyl)-amin 
• 52145-28-5 1,2-bis(pentamethylphenyl)ethane 
• 60144-50-5 <2.2.2.2.2.2>(1,2,3,4,5,6)cyclophane 
• 75279-58-2 (2,4,5-trimethyl-phenyl)-acetonitrile 

Relevant articles and documents

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Isolation, X-ray structures, and electronic spectra of reactive intermediates in Friedel-Crafts acylations

Reactive intermediates in the Friedel-Crafts acylation of aromatic donors are scrutinized upon their successful isolation and X-ray crystallography at very low temperatures. Detailed analyses of the X-ray parameters for the [1:1] complexes of different al

Direct Observation of the Kinetic Acidities of Transient Aromatic Cation Radicals. The Mechanism of Electrophilic Side-Chain Nitration of the Methylbenzenes

The transient cation radicals ArCH3(.+) are spontaneously generated by the 532-nm excitation of the charge-transfer complexes with a 10-ns laser pulse.The decay kinetics of the spectral transients in the presence of added base establish the kinetic acidities (kH) for various methylarene cation radicals with different pyridines and trinitromethide.Such a proton transfer from ArCH3(.+) proceeds with a deuterium kinetic isotope effect of kH/kD ca. 3.Side-chain nitration of hexamethylbenzene (HMB) is shown to proceed in high yields via the intimate triad of reactive fragments II, , that is produced upon the charge-transfer excitation.The subsequent annihilation of the reactive triad II occurs via a rapid succession of bimolecular steps involving either (i) the initial ion-pair collapse of by proton transfer, as shown in Scheme VI, or (ii) the alternative sequence with the initial ion-radical collapse of by homolytic coupling, as shown in Scheme VII.The marked variations of kH/kD with solvent polarity and added innocuous salt (Bu4N(+)ClO4(-)), as reflected in ion-pair separation and the "special" salt effect, serve to effectively distinguish these pathways.The direct bearing of Schemes VI and VII on the mechanism of the thermal (adiabatic) nitration of methylarene side chains with nitric acid is delineated.