1034191-18-8

Basic information

• Product Name: 4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl acetate
• Synonyms: 4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl acetate
• CAS NO: 1034191-18-8
• Molecular Weight: 331.282
• Mol File: 1034191-18-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl acetate(1034191-18-8)
• EPA Substance Registry System: 4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl acetate(1034191-18-8)

Safety Data

• Hazardous Substances Data: 1034191-18-8(Hazardous Substances Data)

Upstream product

• 6309-46-2 4-acetoxybenzyl alcohol 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 1034190-66-3 3-(4-acetyloxybenzyloxycarbonyl)amino-1-propanesulfonic acid sodium salt 
• 1398039-52-5 4-[[[(ferrocenylamino)carbonyl]oxy]methyl]-phenol acetate 

Relevant articles and documents

Esterase-Responsive Polypeptide Vesicles as Fast-Response and Sustained-Release Nanocompartments for Fibroblast-Exempt Drug Delivery

Enzyme-responsive polypeptide vesicles have attracted considerable attention for precision theranostics because of their biocompatibility, biodegradability, and unique secondary conformation transition triggered by the catalytic actions of enzymes. These promising potentials of polypeptide vesicles could be limited in a drug delivery system by the very slow enzyme diffusion rate into vesicles that could reduce the efficacy of the drug. On the other hand, stimuli-responsive polymeric vesicles that respond to stimuli can undergo microstructure destruction for the burst release of drugs, which would penetrate through the membrane of dead cells and the tumor extracellular matrix, inducing acute toxicity to neighboring cells. Here, we designed amphiphilic PEG-polypeptide copolymers containing esterase-labile carbamate-caged primary amines. It was found that the diblock can self-assemble into vesicular structures. Esterase-triggered self-immolative decaging reactions could quickly release the primary amine moiety of monomers that can undergo an amidation reaction for transition of the bilayer of vesicles from hydrophobic to partially hydrophilic. This esterase-responsive process retains the nanostructure of vesicles but permeabilizes the vesicle membrane, which can afford the sustained release of encapsulating drugs. These esterase-responsive polypeptide vesicles mediate selective cytotoxicity in cancer cells with high esterase expression over normal fibroblasts with low esterase, enabling the potent anticancer chemotherapy with minimized side effects.

Dual enzyme-responsive "turn-on" fluorescence sensing systems based on in situ formation of 7-hydroxy-2-iminocoumarin scaffolds

A new strategy for the simultaneous fluorogenic detection of two distinct enzyme activities namely hydrolase (amidase or esterase) and reductase is described. This innovative biosensing method is based on the powerful "covalent-assembly" principle that in

METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID

The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.