6309-46-2

Basic information

• Product Name: 4-(Hydroxymethyl)phenyl acetate
• Synonyms: 4-(Hydroxymethyl)phenyl acetate;Benzyl alcohol, p-hydroxy-, acetate (8CI);4-(Acetyloxy)benzenemethanol;4-Acetoxybenzyl alcohol;Acetic acid 4-hydroxymethylphenyl ester;NSC 42564;p-Acetoxybenzyl alcohol;p-Hydroxymethylphenol acetate
• CAS NO: 6309-46-2
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• Product Categories: Alcohols;Building Blocks;C9;C9 to C10;Chemical Synthesis;Ethers;New Products for Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 6309-46-2.mol
• Article Data: 47

Chemical Properties

• Melting Point: 37-42℃
• Boiling Point: 110℃ (0.001 Torr)
• Flash Point: >110°C
• Appearance: /
• Density: 1.169g/mLat 25℃
• Vapor Pressure: 0.000997mmHg at 25°C
• Refractive Index: n20/D 1.529
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(Hydroxymethyl)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Hydroxymethyl)phenyl acetate(6309-46-2)
• EPA Substance Registry System: 4-(Hydroxymethyl)phenyl acetate(6309-46-2)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 6309-46-2(Hazardous Substances Data)

Usage

General Description

4-(Hydroxymethyl)phenyl acetate is a chemical compound characterized by the presence of an acetate functional group and a hydroxymethyl group attached to a phenyl ring. It falls under the category of aromatic esters and phenols. The compound is stable under normal conditions and does not pose any significant risk or danger upon handling. However, it should be stored correctly to ensure its stability over time. It is used in various chemical reactions due to its ability to react with a variety of other substances. Several safety precautions should be taken when handling this compound to prevent any chemical accidents or hazards from occurring.

InChI:InChI=1/C9H10O3/c1-7(11)12-9-4-2-8(6-10)3-5-9/h2-5,10H,6H2,1H3

Upstream product

• 228106-32-9 acetic acid 4-trityloxymethyl-phenyl ester 
• 878-00-2 4-formylphenyl acetate 
• 228106-33-0 4-trityloxymethyl-phenol 
• 60-29-7 diethyl ether 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 108-05-4 vinyl acetate 
• 80767-12-0 4-hydroxybenzyl acetate 
• 126070-20-0 4-((tert-butyldimethylsilyloxy)methyl)phenol 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 52727-95-4 4-acetoxybenzyl bromide 
• 115287-29-1 Acetic acid 4-trimethylsilanyloxymethyl-phenyl ester 

Downstream Products

• 136825-69-9 di(4-acetoxybenzyl) methylphosphonate 
• 151239-26-8 4-{[({[4-(acetyloxy)phenyl]methoxy}[bis(propan-2-yl)amino]phosphanyl)oxy]methyl}phenyl acetate 
• 86157-54-2 4-(acetoxy)benzyl chloroformate 
• 228106-20-5 Acetic acid 4-((2R,3S,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxymethyl)-phenyl ester 
• 1346128-57-1 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl acetate 
• 1346128-45-7 4-((((3-aminopyridin-4-yl)carbamoyl)oxy)methyl)phenyl acetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 15887-38-4 4-hydroxybenzyl alpha-β-D-glucopyranoside 
• 185068-44-4 di(4-acetoxybenzyl) phosphite 
• 171284-20-1 4-acetoxybenzyl N,N,N’,N’-tetraisopropylphosphoramidite 

Relevant articles and documents

Fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA

We report herein comprehensive investigations of alkylation/sulfur exchange reactions of sulfur-containing substrates including nucleosides such as s2U, m5s2U, s4U, s2A and s2T-incorporated DNA enable by comprehensive screenings of the reagents (2a–2h). It has been proven that iodoacetamide (2a) displays the most promising feasibility toward sulfur-containing substrates including s2T, s2U, m5s2U, s4U and s2A. In sharp contrast, the alkylation process with S-benzyl methanethiosulfonate (BMTS, 2h) displays the best application potential only for s4U. Based on these results, the fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA has been achieved. Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1942044.

A fluorogenic probe using a catalytic reaction for the detection of trace intracellular zinc

Labile zinc plays various roles in cells at low concentrations which most fluorescent probes are not able to detect. Here we report a cephem-based probe which coordinates to zinc and zinc-bound water cleaves the scaffold and releases the fluorophore. In addition, the zinc is recycled and reacts with multiple probes, amplifying the signal. This signal amplification system is useful for the detection of intracellular zinc at low concentrations and has potential for further development of probes with a similar molecular design. This journal is

Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer

In order to improve the antitumor potency of the natural product evodiamine, novel boron-containing evodiamine derivatives were designed by incorporating boronic acid and boronate as trigger units. Boronate derivative 13a could be triggered by reactive oxygen species (ROS) in the HCT116 colon cancer cell line and showed excellent antitumor activity in vitro and in vivo. It induced apoptosis in HCT116 cancer cells in a dose-dependent manner and cell growth arrest at the G2 phase.