10345-79-6

Basic information

• Product Name: 2-chloro-N,N-diethylbenzamide
• Synonyms: 2-chloro-N,N-diethylbenzamide
• CAS NO: 10345-79-6
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• EINECS: 233-754-6
• Mol File: 10345-79-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 331°Cat760mmHg
• Flash Point: 154°C
• Appearance: /
• Density: 1.115g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-chloro-N,N-diethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N,N-diethylbenzamide(10345-79-6)
• EPA Substance Registry System: 2-chloro-N,N-diethylbenzamide(10345-79-6)

Safety Data

• Hazardous Substances Data: 10345-79-6(Hazardous Substances Data)

Usage

General Description

2-chloro-N,N-diethylbenzamide is a chemical compound that belongs to the benzamides class with the molecular formula C11H14ClNO. Benzamides are organic compounds containing a carboxamido substituent attached to a benzene ring, providing various useful properties for this chemical. This specific compound includes chloro, ethyl, and amide functional groups, which could make it potentially useful in various organic syntheses and industrial applications. Its exact properties, such as melting and boiling points, density, and solubility, as well as hazard information, could be obtained from its Material Safety Data Sheet (MSDS). Due to its specific molecular structure and functional groups, it might require special handling and disposal procedures, given its potential hazards.

InChI:InChI=1/C11H14ClNO/c1-3-13(4-2)11(14)9-7-5-6-8-10(9)12/h5-8H,3-4H2,1-2H3

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 109-89-7 diethylamine 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 89-98-5 2-chloro-benzaldehyde 
• 2136-89-2 2-chlorobenzotrichloride 
• 121-44-8 triethylamine 
• 118-91-2 ortho-chlorobenzoic acid 
• 62924-92-9 N,N-diethyl-2-(trimethylsilyl)benzamide 
• 660-68-4 diethyl amine hydrochloride 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 649-15-0 N,N-diethyl-4-methylbenzenesulfonamide 

Downstream Products

• 1696-17-9 N,N-diethylbenzamide 
• 70097-44-8 7-chloro-3-hydroxyisobenzofuran-1(3H)-one 
• 596805-22-0 N,N-diethyl-2-methylsulfanyl-6-chlorobenzamide 
• 610-96-8 methyl chlorobenzoate 
• 95415-54-6 N,N-diethyl-o-chlorothiobenzamide 

Relevant articles and documents

One-Pot Synthesis of Tertiary Amides from Organic Trichlorides through Oxygen Atom Incorporation from Air by Convergent Paired Electrolysis

A convergent paired electrolysis catalyzed by a B12 complex for the one-pot synthesis of a tertiary amide from organic trichlorides (R-CCl3) has been developed. Various readily available organic trichlorides, such as benzotrichloride and its derivatives, chloroform, dichlorodiphenyltrichloroethane (DDT), trichloro-2,2,2-trifluoroethane (CFC-113a), and trichloroacetonitrile (CNCCl3), were converted to amides in the presence of tertiary amines through oxygen incorporation from air at room temperature. The amide formation mechanism in the paired electrolysis, which was mediated by a cobalt complex, was proposed.

Visible light-driven photocatalytic duet reaction catalyzed by the B12-rhodium-titanium oxide hybrid catalyst

The hybrid catalyst composed of the B12 complex and rhodium ion (Rh3+) modified titanium oxide was synthesized for the visible light-driven B12 inspired catalytic reaction. The hybrid catalyst contains 4.93 × 10?6 molg?1 of the B12 complex and 5.43 × 10?5 molg?1 of the Rh(III) ion on the surface of titanium oxide. Visible light irradiation (λ ≧ 420 nm) of the hybrid catalyst in the presence of triethylamine (Et3N) as a sacrificial reagent showed absorption at 390 nm, typical for the Co(I) state of the B12 complex monitored by diffuse reflectance UV–vis analysis, which imply that electron transfer from the titanium oxide to Co(III) center of the B12 complex occurred by the visible light irradiation. Benzotrichloride was converted to N,N-diethylbenzamide by the visible light irradiation catalyzed by the hybrid catalyst in air at room temperature. Both the conduction band electron and valence band hole of the catalyst were utilized for the reaction to form the amide product. The reaction mechanism of the duet reaction was proposed.

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin- 5(9bH)-ones as 5-HT2C receptor agonists

A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT2C agonism with excellent selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compounds such as 38 and 44 were shown to be effective in reducing food intake in an acute rat feeding model.