10347-50-9

Upstream product

• 14578-67-7 4,4-diphenylbutanoic acid 
• 26577-95-7 bis-(3-methoxycarbonyl-propionyl)-peroxide 
• 101-81-5 Diphenylmethane 
• 24104-20-9 2,2-diphenylcyclobutanone 
• 124-41-4 sodium methylate 
• 19179-60-3 methyl 2,2-diphenylcyclopropane-1-carboxylate 
• 121-44-8 triethylamine 
• 75-50-3 trimethylamine 
• 86419-96-7 2-(2,2-diphenyl-ethyl)-malonic acid 
• 117-34-0 2,2-diphenylacetic acid 
• 1883-32-5 2,2-diphenyl ethanol 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 6944-27-0 2,2-diphenylethyl 4-methylbenzenesulfonate 
• 158660-01-6 Methyl 4,4-diphenyl-3-butenoate 

Downstream Products

• 859811-51-1 1-hydroxy-1.1.4.4-tetraphenyl-butane 
• 14578-67-7 4,4-diphenylbutanoic acid 
• 56740-71-7 4,4-diphenyl-1-butanol 
• 38899-54-6 2-methyl-5,5-diphenyl-2-pentanol 
• 929219-66-9 4,4-diphenylbutyl 4-methylbenzenesulfonate 
• 103870-65-1 4-(4,4-diphenyl-butyl)-piperazine-1-carboxylic acid ethyl ester 
• 6887-96-3 1-(4,4-diphenylbutyl)piperazine 
• 29619-51-0 1,1,4,4-tetraphenyl-but-1-ene 
• 13556-56-4 1,2,3,4-tetrahydro-1,1-dimethyl-4-phenylnaphthalene 
• 80654-58-6 [2-(3,4-Dimethoxy-phenyl)-ethyl]-(4,4-diphenyl-butyl)-amine 
• 80661-12-7 4-[2-(4,4-Diphenyl-butylamino)-ethyl]-phenol 
• 80654-59-7 (4,4-Diphenyl-butyl)-(2-p-tolyl-ethyl)-amine 
• 36265-55-1 1,1-diphenyl-4-bromobutane 

Relevant academic research and scientific papers

Development of efficient palladium catalysts for alkoxycarbonylation of alkenes

Herein, we report a general and efficient Pd-catalysed alkoxycarbonylation of sterically hindered and demanding olefins including a variety of tri-, tetra-substituted and 1,1-disubstituted alkenes. In the presence of 1,3-bis(tert-butyl(pyridin-2-yl)phosphanyl)propane L3 or 1,4-bis(tert-butyl(pyridin-2-yl)phosphanyl)butane L4 the desired esters are obtained in good yields and selectivities. Similar transformation is obtained using tertiary ether as showcased in the carbonylation of MTBE to the corresponding linear ester in high yield and selectivity.

New 1,3-dioxolane and 1,3-dioxane derivatives as effective modulators to overcome multidrug resistance

Multidrug resistance (MDR) to antitumor agents represents a major obstacle to a successful chemotherapy of cancer. Overexpression of P-glycoprotein (p-gp) seems to be the major factor responsible for MDR. A large number of chemically unrelated compounds are known to interact with p-gp resulting in a decreasing resistance. In our efforts related to structure-activity studies of new potential MDR reversal agents we synthesized a series of compounds that differ in the aromatic core structure, the linker, and the basic moiety. For our search of new aromatic core structures we synthesized novel 2,2-diphenyl-1,3-dioxolane, 2,2- diphenyl-1,3-dioxane, and 4,5-diphenyl-1,3-dioxolane derivatives. A range of lipophilic linker structures and protonable basic moieties were synthesized and investigated to optimize the structure of the potential MDR-modulators. The compounds were tested in vitro using human Caco-2 cells. Both the cytotoxicity of the synthons and their ability to resensitize the cells were determined with a MTT assay. The results show that at low concentration various substances reverse tumor cell MDR. Some of the new structures show better effects than established modulators like trifluoperazine.

SIP3 RECEPTOR ANTAGONIST

PROBLEM TO BE SOLVED: To obtain a compound having selective SIP3 receptor antagonism and a medicine containing the same. SOLUTION: The medicine comprises an aminopropionic acid derivative represented by general formula (1) (R1 is a hydrogen atom or a lower alkyl group; R2 is formula A; A is CO or CH2; E is an oxygen atom or an NR4; R3 is a lower alkyl group or formula B; G is CH, a nitrogen atom or a phosphorus atom; J is an oxygen atom or a sulfur atom; R4 is a hydrogen atom or a lower alkyl group; R5, R6 and R7 are each the same or different and a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a nitro group or a haloalkyl group; m is an integer of 1-8; n is an integer of 1-5) or its pharmaceutically permissible salt as an active ingredient.

Photochemical Addition of Tertiary Amines to Electrophilic Cyclopropranes via Single Electron Transfer

Irradiation of arylcyclopropanes bearing at least one electron-withdrawing group with a tertiary amine in acetonitrile resulted in the formation of the regioselective addition product of the amine along with the reduction product.