103476-92-2

Basic information

• Product Name: Naphtho[2,1-b]furan-2-ol, dodecahydro-3a,6,6,9a-tetramethyl-
• CAS NO: 103476-92-2
• Molecular Formula: C16H28O2
• Molecular Weight: 252.397
• Mol File: 103476-92-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Naphtho[2,1-b]furan-2-ol, dodecahydro-3a,6,6,9a-tetramethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphtho[2,1-b]furan-2-ol, dodecahydro-3a,6,6,9a-tetramethyl-(103476-92-2)
• EPA Substance Registry System: Naphtho[2,1-b]furan-2-ol, dodecahydro-3a,6,6,9a-tetramethyl-(103476-92-2)

Safety Data

• Hazardous Substances Data: 103476-92-2(Hazardous Substances Data)

Upstream product

• 564-20-5 (3aR)-(+)-sclareolide 
• 138171-15-0 8-acetoxy-labdanolic acid 
• 145511-17-7 15-nor-8-acetoxy-13-labdene 
• 469-11-4 labdanolic acid 
• 14162-41-5 (13R,14RS)-14,15-epoxylabdane-8,13-diol 
• 64661-55-8 (12R)-8α,12-epoxy-14,15-bisnorlabdan-13-one 
• 5153-92-4 sclareol oxide 
• 159970-19-1 8α,12-epoxy-13,14,15,16-tetranorlabdan-12-ol acetate 
• 145511-19-9 15-nor-8-hydroxy-12-labdene 

Downstream Products

• 564-20-5 (3aR)-(+)-sclareolide 
• 72853-86-2 (1R,2S)-1-(2,5-Dimethoxy-benzyl)-1,2,5,5-tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalene 
• 20404-65-3 (-)-(2R,4aS,8aS)-2,5,5,8a-Tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1(2H)-one 
• 68985-11-5 [(4aS,8aS)-3,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethylnaphthalen-1-yl]acetaldehyde 
• 88862-14-0 ((4aS,8aS)-2,5,5,8a-Tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-acetaldehyde 
• 913379-65-4 C₂₄H₃₄O₂ 
• 39707-54-5 (-)-ent-zonarol 
• 250146-75-9 ent-isozonarol 
• 39707-56-7 (+)-zonarone 
• 39707-59-0 ent-isozonarone 
• 752211-90-8 4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid 
• 1376654-81-7 C₃₆H₄₄O₄ 
• 1376654-71-5 C₂₃H₃₄O₃ 
• 1376654-68-0 (1R,2R,4aS,8aS)-2,5,5,8a-tetramethyl-1-(4-(trifluoromethyl)benzyl) decahydronaphthalen-2-ol 

Relevant articles and documents

Spiroperoxy lactones from furans in one pot: Synthesis of (+)-premnalane A

A [4+2]-cycloaddition between singlet oxygen and a furan, followed by an ene reaction and ketalization, in one synthetic operation, was used for the synthesis of (+)-premnalane A. The first example of a singlet oxygen ene reaction that furnishes exclusively a Z-double bond is noted.

Synthesis of Cyclosiphonodictyol A and Its Bis(sulfato)

The first synthesis of the marine benzoxepane hydroquinone cyclosiphonodictyol A and its bis(sulfato) from commercial (+)-sclareolide is reported. The key steps of the synthetic sequence (11 steps, 46% global) are the nucleophilic attack of a hindered tertiary alkoxide, a ring-closing metathesis reaction, and the Diels-Alder cycloaddition of a dienol acetate.

Synthesis of pelorol and its analogs and their inhibitory effects on phosphatidylinositol 3-kinase

There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper, the synthesis of pelorol has been completed, and the synthesis of some intermediates has been optimized and scaled up. Five pelorol analogs have also been prepared. Preliminary biological activity testing demonstrated that compounds 5 and 6 might be potential lead compounds for cancer therapy.