752211-90-8Relevant academic research and scientific papers
Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads
Hu, Nvdan,Kong, Wenlong,Li, Shengkun,Song, Baoan,Wang, Xia
supporting information, (2021/10/16)
The diversity of drimane hydroquinones was significantly expanded by the facile construction of (+)-chromazonarol relevant natural products, isomers, and analogues for the discovery of new pharmaceutical leads. The structure-activity relationship of (+)-c
Scalable, divergent synthesis of meroterpenoids via "borono- sclareolide"
Dixon, Darryl D.,Lockner, Jonathan W.,Zhou, Qianghui,Baran, Phil S.
, p. 8432 - 8435 (2012/07/14)
A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of "borono- sclareolide", a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.
