10350-68-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with improved therapeutic properties. Its unique structure allows for the creation of molecules with specific biological activities, making it a valuable asset in drug discovery and design.
Used in Research and Development:
In the realm of scientific research, 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine serves as a crucial compound for exploring new chemical reactions and understanding the reactivity of heterocyclic systems. Its presence in various synthetic pathways provides insights into the mechanisms of organic synthesis and the potential for creating novel chemical entities.
Used in Material Science:
Although not explicitly mentioned in the provided materials, the compound's structural attributes suggest that 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine may also find applications in material science. Its heterocyclic nature could contribute to the development of new materials with specific properties, such as those with enhanced stability or reactivity in various chemical processes.
Used in Agrochemicals:
Similarly, while not directly stated, the compound's potential applications in agrochemicals can be inferred from its reactivity and structural features. 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine could be utilized in the design of new agrochemicals, such as pesticides or herbicides, that exhibit increased effectiveness and selectivity due to its unique molecular interactions.

InChI:InChI=1/C8H7N3O/c1-6-10-8(11-12-6)7-4-2-3-5-9-7/h2-5H,1H3

Upstream product

• 1772-01-6 2-pyridylamidoxime 
• 127-19-5 N,N-dimethyl acetamide 
• 108-24-7 acetic anhydride 
• 1333500-31-4 C₇H₉N₃O₄ 
• 100-70-9 2-Cyanopyridine 
• 1772-01-6 (Z)-N'-hydroxy-pyridine-2-carboxamidine 
• 6558-63-0 3-methylimidazo<1,5-a>pyridine 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Efficient and convenient protocol for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles using HClO4-SiO2 as a heterogeneous recyclable catalyst

Silica-supported perchloric acid (HClO4SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.

A simple and straightforward protocol to 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids

A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acids and amidoximes in the presence of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N-methylmorpholine (NM1 B) has been employed to synthesize a variety of 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields. The methodology has been applied for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

THERMAL REACTIONS OF ARYLAMIDOXIMES

The effect of heat on arylamidoximes, 1a-g, has been examined.When acetic acid was used as solvent, amidoximes, 1a-g, provided three products, viz., 3,5-bis-aryl-1,2,4-oxadiazoles, 2a-g, 3-aryl-5-methyl-1,2,4-oxadiazoles, 3a-g, and a small quantity of an

The Nitration of Imidazopyridines

Imidazopyridines in acetic acid solution are readily nitrated by nitric acid-sulphuric acid, although in some instances treatment of the base hydrogensulphate with nitric acid-acetic acid is preferred.Nitration occurs most readily in the 1-position, but 3-nitration occurs if the 1-position is already substituted.