10350-68-2

Basic information

• Product Name: 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine
• Synonyms: 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine
• CAS NO: 10350-68-2
• Molecular Formula: C8H7 N3 O
• Molecular Weight: 161.1607
• Mol File: 10350-68-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 313.7°Cat760mmHg
• Flash Point: 151.4°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 0.000898mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine(10350-68-2)
• EPA Substance Registry System: 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine(10350-68-2)

Safety Data

• Hazardous Substances Data: 10350-68-2(Hazardous Substances Data)

Usage

General Description

"2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine" is a chemical compound with the molecular formula C8H7N3O. It is a heterocyclic compound that contains a pyridine ring and an oxadiazole ring. 2-(5-Methyl-1,2,4-oxadiazol-3-yl)pyridine is often used in research and development, particularly in the pharmaceutical industry, where it may be used as a building block for the synthesis of various biologically active compounds. Its unique structure and reactivity make it a valuable tool for the design and development of new drugs and pharmaceuticals. Additionally, it may also have potential applications in other fields such as material science and agrochemicals.

InChI:InChI=1/C8H7N3O/c1-6-10-8(11-12-6)7-4-2-3-5-9-7/h2-5H,1H3

Upstream product

• 6558-63-0 3-methylimidazo<1,5-a>pyridine 
• 1772-01-6 2-pyridylamidoxime 
• 127-19-5 N,N-dimethyl acetamide 
• 108-24-7 acetic anhydride 
• 1333500-31-4 C₇H₉N₃O₄ 
• 100-70-9 2-Cyanopyridine 
• 1772-01-6 (Z)-N'-hydroxy-pyridine-2-carboxamidine 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

A simple and straightforward protocol to 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids

A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acids and amidoximes in the presence of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N-methylmorpholine (NM1 B) has been employed to synthesize a variety of 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields. The methodology has been applied for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

The Nitration of Imidazopyridines

Imidazopyridines in acetic acid solution are readily nitrated by nitric acid-sulphuric acid, although in some instances treatment of the base hydrogensulphate with nitric acid-acetic acid is preferred.Nitration occurs most readily in the 1-position, but 3-nitration occurs if the 1-position is already substituted.