103517-58-4

Upstream product

• 346689-44-9 4-chloro-N-(2-iodophenyl)benzamide 
• 37038-65-6 N-(2-bromophenyl)-4-chlorobenzamide 
• 88-74-4 2-nitro-aniline 
• 122-01-0 4-chloro-benzoyl chloride 
• 95-54-5 1,2-diamino-benzene 
• 74-11-3 para-chlorobenzoic acid 
• 33489-99-5 N-(2-nitrophenyl)-4-chlorobenzamide 

Downstream Products

• 866251-01-6 (benzotriazol-1-yl)(4-chlorophenyl)methanethione 
• 95-54-5 1,2-diamino-benzene 
• 74-11-3 para-chlorobenzoic acid 
• 1019-85-8 2-(4-chlorophenyl)benzimidazole 

Relevant academic research and scientific papers

Copper-catalyzed regioselective 2-amination of o-haloanilides with aqueous ammonia

An efficient Cu(II)-vasicine catalytic system has been developed for intramolecular C[sbnd]N bond formation. In this way, regioselective 2-amination of o-haloanilides with aqueous ammonia in EtOH has been achieved. This strategy provides several advantages, such as good regioselectivity, high yields and functional group tolerance.

Azobenzene-diamides as Photopharmacological Ligands for Insect Ryanodine Receptor

Photoresponsive ligands are powerful tool compounds for studying receptor function with spatiotemporal resolution. However, to the best of our knowledge, such a ligand is not available for the ryanodine receptor (RyR). Herein, we present a photochromic ligand (PCL) for insect RyR by decorating chlorantraniliprole (CHL) with photoswitchable azobenzene (AB). We demonstrated that one potent ligand, named ABCHL13, shows light-induced reversible trans-cis isomerization and 3.5-fold insecticidal activity decrease toward oriental armyworm (Mythimna separata) after UV-light irradiation, that is, trans-ABCH13 has higher activity than the cis-ABCH13. ABCHL13 enables optical control over intracellular Ca2+ release in dorsal unpaired median (DUM) neurons of M. separata and American cockroach (Periplaneta americana) and cardiac function of P. americana. Our results provide a first photopharmacological toolkit that is applicable to light-dependent regulation of RyR and heart beating.

Facile synthesis of thiazoles via an intramolecular thia-Michael strategy

A mild and efficient method for the synthesis of substituted thiazoles is reported via one-pot N-desilylation, thioacylation/oxythioacylation/thiothioacylation followed by thia-Michael cycloisomerisation. This method has a general applicability to introdu