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Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-N-(2-iodophenyl)benzamide, 97% is used as a research chemical for the development of potential drugs targeting the D3 receptor. Its structural diversity in the aryl moiety allows for the fine-tuning of its affinity, making it a valuable tool in the discovery of new therapeutic agents with (sub)nanomolar D3 receptor affinity.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-Chloro-N-(2-iodophenyl)benzamide, 97% serves as a key intermediate in the synthesis of novel compounds with potential therapeutic applications. Its unique structure and properties make it an attractive candidate for further exploration and optimization in drug design.

Upstream product

• 615-43-0 2-iodophenylamine 
• 619-56-7 4-chlorobenzamide 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 31913-75-4 4-chloro-N-(2-hydroxyphenyl)benzamide 
• 1141-35-1 2-(4-chlorophenyl)benzoxazole 
• 18600-52-7 2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 103517-58-4 2'-amino-4-chlorobenzanilide 
• 6265-91-4 2-(4-chlorophenyl)benzothiazole 
• 7455-77-8 2-(4-chlorophenyl)-4(3H)-quinazolinone 
• 6833-15-4 4-chlorobenzanilide 

Relevant academic research and scientific papers

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

Lewis Acid Catalyzed Atom-Economic Synthesis of C2-Substituted Indoles from o-Amido Alkynols

Herein we have disclosed a Zn(OTf)2 catalyzed synthesis of C2-alkyl substituted indole derivatives via unprecedented carbonyl group migration from o-amido alkynols. The key features of this protocol involve N,O-carbonyl group migration, broad s

One-pot preparation of 2-(alkyl)arylbenzoselenazoles from the corresponding N-(acetyl)benzoyl-2-iodoanilines via a microwave-assisted methodology

We report here the first example of a one-pot synthesis of 2-(alkyl)arylbenzoselenazoles from N-(acetyl)benzoyl-2-iodoanilines. The reaction was carried out in the presence of Woollins' reagent under microwave irradiation and resulted in moderate to good yields.

Iodine-catalyzed, stereo- and regioselective synthesis of 4-arylidine-4H-benzo[d][1,3]oxazines and their applications for the synthesis of quinazoline 3-oxides

4-Benzylidene-2-aryl-4H-benzo[d][1,3] oxazines have been synthesized with high stereoselectivity and regioselectivities from 2-alkynylbenzamides in the presence of a catalytic amount of I2. In the reaction mechanism, iodine plays a key role in

Parallel synthesis of a library of benzoxazoles and benzothiazoles using ligand-accelerated copper-catalyzed cyclizations of ortho-halobenzanilides

A general method for the formation of benzoxazoles via a copper-catalyzed cyclization of ortho-haloanilides is reported. This approach complements the more commonly used strategies for benzoxazole formation which require 2-aminophenols as substrates. The reaction involves an intramolecular C-O cross-coupling of the ortho-haloanilides and is believed to proceed via an oxidative insertion/reductive elimination pathway through a Cu(I)/Cu(III) manifold. The reaction is also applicable to the formation of benzothiazoles. A variety of ligands including 1,10-phenanthroline and N,N′- dimethylethylenediamine were shown to provide ligand acceleration/stabilization in the reaction. Optimal conditions for cyclization used a catalyst combination of CuI and 1,10-phenanthroline (10 mol %). The method was amenable to a parallel-synthesis approach, as demonstrated by the synthesis of a library of benzoxazoles and benzothiazoles substituted at various positions in the ring. Most examples utilized the cyclization of ortho-bromoanilides, but orthoiodoanilides and ortho-chloroanilides also undergo a reaction under these conditions. The rate of reaction of the ortho-haloanilides follows the order I > Br > Cl, consistent with oxidative addition being the rate-determining step.