1035227-29-2

Upstream product

• 1035229-41-4 N-cyclohexyl-N-(2,2-dimethoxyethyl)acrylamide 
• 99863-45-3 N-(2,2-dimethoxyethyl)cyclohexanamine 
• 1035229-43-6 tert-butyl(2-(N-cyclohexylacrylamido)ethyl)(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate 
• 64-04-0 phenethylamine 
• 1035492-00-2 8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1035229-34-5 8-(2-azidoacetyl)-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1035229-33-4 5-(benzyloxy)-8-(2-chloroacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1035229-32-3 8-acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 108-91-8 cyclohexylamine 
• 871101-87-0 1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone 
• 1035229-31-2 1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone 
• 89684-58-2 1-(2,4-dihydroxy-3-nitrophenyl)ethanone 
• 601-89-8 2-nitroresorcinol 
• 1035229-42-5 N-cyclohexyl-N-(2-oxoethyl)acrylamide 

Relevant academic research and scientific papers

SMYD2 INHIBITORS

The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure-activity relationships of a previous