1035229-32-3

Usage

Uses

Used in Pharmaceutical Industry:
8-Acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one is used as a potential pharmaceutical agent for its possible biological activities. The presence of the benzo[b][1,4]oxazin ring, acetyl group, and benzyloxy substituents may endow 8-Acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one with specific pharmacological properties that could be harnessed for the development of new drugs.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 8-Acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one serves as a subject of study for its structural and functional characteristics. Researchers may investigate its interactions with biological targets, its potential as a lead compound for drug discovery, and its capacity to modulate biological pathways relevant to various diseases.

Upstream product

• 871101-87-0 1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone 
• 79-04-9 chloroacetyl chloride 
• 601-89-8 2-nitroresorcinol 
• 89684-58-2 1-(2,4-dihydroxy-3-nitrophenyl)ethanone 
• 1035229-31-2 1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone 

Downstream Products

• 1035229-33-4 5-(benzyloxy)-8-(2-chloroacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1035229-34-5 8-(2-azidoacetyl)-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1035229-43-6 tert-butyl(2-(N-cyclohexylacrylamido)ethyl)(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate 
• 1092407-74-3 5-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]oxazin-3-one 
• 1092407-75-4 5-benzyloxy-8-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-2-chloro-ethyl]-4H-benzo[1,4]oxazin-3-one 
• 1092407-76-5 8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one 

Relevant academic research and scientific papers

SMYD2 INHIBITORS

The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure-activity relationships of a previous

NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA-2 RECEPTORS

The present invention relates to named compounds of the formula (I) having both M3 receptor antagonist and β2 agonist activity; compositions comprising such compounds; the use of such compounds in therapy (such as respiratory tract disorders); and a metho

BENZOXAZINONE DERIVATIVES ACTING AS BETA2-ADRENORECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISORDERS

The present invention provides a compound of formula (I), wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

BICYCLOR [2.2.1] HEPT-7-YLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES AND CONDITIONS IN WHICH M3 MUSCARINIC RECEPTOR ACTIVITY AND BETA-ADRENERGIC ACTIVITY ARE IMPLICATED

The present invention relates to compounds of formula (I) having muscarinic M3 receptor and β-adrenergic receptor modulating activity; wherein R1, R2, R3 and X are as defined herein.

AMINE DERIVATIVES AND THEIR USE IN BETA-2-ADRENORECEPTOR MEDIATED DISEASES

The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and E are as defined in the specification, processes