1035229-33-4

Usage

Uses

Used in Pharmaceutical Research and Development:
5-(Benzyloxy)-8-(2-chloroacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one is used as a building block for the synthesis of various types of compounds in the pharmaceutical industry. Its unique structure and properties make it an important intermediate in the development of new drugs for the treatment of various diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-(Benzyloxy)-8-(2-chloroacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one is utilized for the development of bioactive compounds. Its functional groups allow for the construction of diverse chemical structures, contributing to the advancement of novel therapeutic agents.

Upstream product

• 871101-87-0 1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone 
• 1035229-31-2 1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone 
• 89684-58-2 1-(2,4-dihydroxy-3-nitrophenyl)ethanone 
• 601-89-8 2-nitroresorcinol 
• 1035229-32-3 8-acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one 

Downstream Products

• 1035229-34-5 8-(2-azidoacetyl)-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1092407-75-4 5-benzyloxy-8-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-2-chloro-ethyl]-4H-benzo[1,4]oxazin-3-one 
• 1092407-76-5 8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one 

Relevant academic research and scientific papers

SMYD2 INHIBITORS

The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure-activity relationships of a previous

NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA-2 RECEPTORS

The present invention relates to named compounds of the formula (I) having both M3 receptor antagonist and β2 agonist activity; compositions comprising such compounds; the use of such compounds in therapy (such as respiratory tract disorders); and a metho

BENZOXAZINONE DERIVATIVES ACTING AS BETA2-ADRENORECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISORDERS

The present invention provides a compound of formula (I), wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

BICYCLOR [2.2.1] HEPT-7-YLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES AND CONDITIONS IN WHICH M3 MUSCARINIC RECEPTOR ACTIVITY AND BETA-ADRENERGIC ACTIVITY ARE IMPLICATED

The present invention relates to compounds of formula (I) having muscarinic M3 receptor and β-adrenergic receptor modulating activity; wherein R1, R2, R3 and X are as defined herein.

AMINE DERIVATIVES AND THEIR USE IN BETA-2-ADRENORECEPTOR MEDIATED DISEASES

The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and E are as defined in the specification, processes