1035229-34-5Relevant academic research and scientific papers
SMYD2 INHIBITORS
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Paragraph 0118, (2016/02/20)
The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.
Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Sweis, Ramzi F.,Wang, Zhi,Algire, Mikkel,Arrowsmith, Cheryl H.,Brown, Peter J.,Chiang, Gary G.,Guo, Jun,Jakob, Clarissa G.,Kennedy, Steven,Li, Fengling,Maag, David,Shaw, Bailin,Soni, Nirupama B.,Vedadi, Masoud,Pappano, William N.
supporting information, p. 695 - 700 (2015/06/30)
A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure-activity relationships of a previous
NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA-2 RECEPTORS
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Page/Page column 50-51, (2010/04/03)
The present invention relates to named compounds of the formula (I) having both M3 receptor antagonist and β2 agonist activity; compositions comprising such compounds; the use of such compounds in therapy (such as respiratory tract disorders); and a metho
BENZOXAZINONE DERIVATIVES ACTING AS BETA2-ADRENORECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISORDERS
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Page/Page column 33-34, (2010/01/12)
The present invention provides a compound of formula (I), wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
AMINE DERIVATIVES AND THEIR USE IN BETA-2-ADRENORECEPTOR MEDIATED DISEASES
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Page/Page column 86, (2008/12/06)
The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and E are as defined in the specification, processes
