1035677-71-4

Upstream product

• 917871-11-5 (R)-(E)-(+)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-penten-1-ol 
• 1195779-19-1 C₃₀H₄₃NO₄SSi 
• 92817-88-4 (2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal 
• 95514-04-8 (R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol 

Downstream Products

• 1035677-72-5 (2R,3R,4S)-5-(tert-butyldiphenylsilyloxy)2,4-dimethylpentane-1,3-diol 
• 412908-67-9 (3R,4S)-5-(tert-butyldiphenylsilyloxy)-4-methylpent-1-en-3-ol 
• 1427556-32-8 (2S,3R)-3-methoxy-5-[(4-methoxybenzyl)oxy]-2-methylpentan-1-ol 
• 301230-10-4 (3R,4S)-5-(tert-butyldiphenylsilyloxy)-3-methoxy-4-methylpentan-1-ol 
• 603994-09-8 (2R,3R)-3-methoxy-5-(4'-methoxybenzyloxy)-2-methylpentanal 

Relevant academic research and scientific papers

Approaches towards the total synthesis of carolacton: Synthesis of C1-C16 fragment

Abstract A stereoselective synthesis of the C1-C16 segment of biofilm inhibitor carolacton has been achieved. The synthetic strategy involves Sharpless asymmetric epoxidation, Roush crotylation, Steglich esterification, RCM reaction and selective reduction of a disubstituted olefin in the presence of a trisubstituted olefin using in situ generated diimide.

A highly efficient methodology of asymmetric epoxidation based on a novel chiral sulfur ylide

A new type of chiral sulfur ylides has been synthesized and their reactivities against carbonyl compounds tested, showing a high degree of stereoselectivity in the formation of trans epoxy amides under very mild reaction conditions.

Formal total synthesis of (-)-spongidepsin

The formal total synthesis of (-)-spongidepsin is described. Three fragments I, II, and III were first prepared from readily available starting materials and then assembled to the target compound. The key steps involved in the synthesis are asymmetric α-hydroxylation, Ender's alkylation, and ring-closing metathesis reactions. An alternative route for the fragment II is also achieved involving Sharpless asymmetric epoxidation and Gilman's alkylation as key reactions.