103575-36-6Relevant academic research and scientific papers
Dealkylative intercepted rearrangement reactions of sulfur ylides
Empel, Claire,Hock, Katharina J.,Koenigs, Rene M.
supporting information, p. 338 - 341 (2019/01/09)
Sulfur ylides are well-known to undergo sigmatropic rearrangement reaction. Herein, we describe a novel reactivity of sulfur ylides, which provides access to the product of a formal functional group metathesis upon dealkylative interception of the rearrangement process. Using a simple iron catalyst and in situ generated diazoalkanes this method provides access to α-mercaptoacetonitrile derivatives.
Cs2CO3-promoted carbon–sulfur bond construction via cross dehydrogenative coupling of thiophenols with acetonitrile
Chen, Qian,Huang, Yulin,Wang, Xiaofeng,Wen, Chunxiao,Yan, Xinxing,Zeng, Jiekun
supporting information, p. 3928 - 3931 (2017/09/21)
A novel protocol for the construction of carbon–sulfur bonds has been achieved via halogen-free Cs2CO3-promoted cross dehydrogenative coupling (CDC) of thiophenols with acetonitrile. This transformation provides a straightforward route to the synthesis of sulfenylated acetonitriles in up to 80% yield.
FLAP MODULATORS
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Paragraph 2246, (2015/11/03)
The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, R2, R3, R3′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention
Use of (Z)-β-(2-fluorobenzenesulfonyl)vinylamines as novel synthons in the synthesis of 1,4-benzothiazine derivatives
Tsui, Gavinchit,Singjunla, Yuttapong,Lautens, Mark
experimental part, p. 1359 - 1364 (2012/06/30)
A novel synthetic route for arylated 1,4-benzothiazine derivatives has been developed. This method utilizes a key intramolecular nucleophilic aromatic substitution step of the corresponding (Z) - (2-fluorobenzenesulfonyl)vinylamine intermediate to construct the benzothiazine ring. A wide range of aryl and heteroaryl substituent groups can be installed from commercial boronic acids. Both mono- and diarylated products have been synthesized in good yields and with good functional group tolerance. Georg Thieme Verlag Stuttgart · New York.
Palladium-catalyzed chemoselective intramolecular cyclization of 2-bromoaryl alkenenitriles
Deng, Jui-Hui,Tai, Huo-Mu,Yang, Chau-Chen
, p. 327 - 341 (2007/10/03)
The chemoselectivity in the palladium-catalyzed intramolecular cyclization of 2-(o-bromoaryl)alkenenitriles depends on the nature of α-substitutents. 2-(o-Bromoanilino)alkenenitriles attacked the cyano group, followed by the cyano group transposition and
