103607-65-4

Upstream product

• 91255-14-0 α-Cyano-β-N-phenylaminocrotonamide 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 120650-99-9 (Z)-2-Cyano-3-phenylamino-but-2-enoic acid amide 
• 62-53-3 aniline 
• 62321-92-0 α-cyano-β-dimethylaminocrotonamide 
• 120651-05-0 α-cyano-β-dimethylaminocrotonamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 103607-70-1 3-cyano-4-phenylamino-1,2-dihydropyridin-2-one 
• 108958-64-1 4-anilino-5-formyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 103589-58-8 2-(3-Isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-4-phenylamino-nicotinonitrile 
• 103607-75-6 2-chloro-3-cyano-4-anilinopyridine 
• 370844-73-8 4-cyano-3-(phenylthio)benzo[b][1,6]naphthyridine 
• 108958-65-2 3-carbamido-4-anilino-2-pyridone 

Relevant academic research and scientific papers

CPAP-TUBULIN MODULE

The invention relates to CPAP-tubulin inhibitors having the general formula (1) or a physiologically acceptable salt thereof; and their use as cancer therapeutics.

Synthesis and hydrolytic cleavage of 1-aryl-5-cyano-6-(2- dimethylaminovinyl)-4-oxo(thioxo)-1,4-dihydropyrimidines

1-Aryl-5-cyano-6-(2-dimethylaminovinyl)-4-oxo-1,4-dihydropyrimidines and their 4-thioxo analogs, which were prepared in three steps from cyanoacetamide and cyanothioacetamide, respectively, were subjected to hydrolysis. In aqueous AcOH, hydrolysis of N-(dimethylaminomethylene)-2-cyano-5-dimethylamino-2,4- pentadieneamide derivatives containing amino groups at position 3 afforded formylpyridones. The reaction of 2-cyano-3-dimethylaminothiocrotonamide with DMF dimethyl acetal gave rise to 3-cyano-4-dimethylamino-2-methylthiopyridine.