10364-05-3

Usage

Uses

Used in Organic Synthesis:
1,4-Diiodobicyclo[2.2.2]octane is used as a reagent in organic synthesis for its unique structural features and stability. It aids in the preparation of complex organic molecules, facilitating various chemical reactions due to its low reactivity.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 1,4-Diiodobicyclo[2.2.2]octane is utilized as a starting material or intermediate in the development of new drugs and therapeutic compounds. Its potential medicinal applications are currently under investigation, highlighting its importance in the discovery and synthesis of novel pharmaceutical agents.
Used in Medicinal Chemistry:
1,4-Diiodobicyclo[2.2.2]octane serves as a key component in medicinal chemistry, where it is employed to design and synthesize compounds with potential therapeutic effects. Its unique properties make it a promising candidate for creating new medicines and improving existing treatments.

InChI:InChI=1/C8H12I2/c9-7-1-2-8(10,5-3-7)6-4-7/h1-6H2

Upstream product

• 10364-04-2 bicyclo[2.2.2]octane-1,4-dibromide 
• 1194-44-1 1,4-dihydroxybicyclo[2.2.2]octane 
• 1123-39-3 1,4-Dichloro-bicyclo<2.2.2>octane 
• 59880-84-1 1,4-Dimethoxy-bicyclo<2.2.2.>octane 
• 54774-94-6 4-acetoxybicyclo<2.2.2>octan-1-ol 
• 711-02-4 1,4-bicyclo[2.2.2]octanedicarboxylic acid 
• 10364-35-9 1,4-Diacetoxybicyclo<2.2.2>octane 

Downstream Products

• 59880-84-1 1,4-Dimethoxy-bicyclo<2.2.2.>octane 
• 74467-18-8 4-Iodo-1-bicyclo<2.2.2>octyl Methyl Ether 
• 10364-04-2 bicyclo[2.2.2]octane-1,4-dibromide 
• 74467-53-1 4-(1,1'-Bibicyclo<2.2.2>octyl)yl diphenylcarbinol 
• 74467-52-0 4-(1,1'-Bibicyclo<2.2.2>octyl)yl Phenyl Ketone 
• 74467-38-2 1-Bicyclo<2.2.2>octyl Cyclohexyl Ketone 
• 931-98-6 1-Iodobicyclo<2.2.2>octane 

Relevant academic research and scientific papers

Molecular Rods: Synthesis and Properties

Our earlier synthetic methodology affording bicyclooctyl -rod and -rod systems proved inadequate for -rods.New synthetic approaches were developed, and - and -rod molecules were obtained.Sodium-potassium coupling was employed to afford the longer rod units.A radical anion approach gave lower yields.Hybrid rods with aromatic rings interposed were also synthesized.Rods of 9.2-, 9.7-, 13.4-, 13.9-, and 18.2-Angstroem length were included in this study.Consideration of rod chirality suggests each bicyclooctane rod unit to be stereogenic, either P (clockwise) or M (anticlockwise).Thus, in a -rod there are enantiomers and in a -rod there are diastereomers.Molecular mechanics treatment of rod stereoisomerization was carried out.Interconversion of enantiomers of the -rod and diastereomers of the -rods should be very rapid at room temperature.X-ray analysis of the 4,4'-dimethoxy--rod reveals an achiral conformation.AM1 quantum mechanics computations were carried out on -rod radical cations and bridgehead cations.

SYNTHESIS OF BRIDGEHEAD CHLORO-, BROMO- AND IODOBICYCLOOCTANES

The paper describes transformations of hydroxy-, acetoxy- or methoxy-bridgehead bicyclooctanes into bridgehead chloro, bromo or iodo derivatives by action of inorganic halides in the medium of orthophosphoric or polyphosphoric acids.

Rod-Like Organic Molecules. Energy-Transfer Studies Using Single-Photon Counting

The synthesis of rod-like molecules was devised wherein the rods were composed of bicyclooctane units bonded bridgehead to bridgehead.Various end chromophores were placed at the terminal bridgehead sites of -rods and -rods, these being consti