1036406-57-1

Basic information

• Product Name: diethyl (4-methoxyphenyl)-N-(4-fluorophenyl)aminomethylphosphonate
• Synonyms: diethyl (4-methoxyphenyl)-N-(4-fluorophenyl)aminomethylphosphonate
• CAS NO: 1036406-57-1
• Molecular Weight: 367.357
• Mol File: 1036406-57-1.mol

Chemical Properties

• CAS DataBase Reference: diethyl (4-methoxyphenyl)-N-(4-fluorophenyl)aminomethylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (4-methoxyphenyl)-N-(4-fluorophenyl)aminomethylphosphonate(1036406-57-1)
• EPA Substance Registry System: diethyl (4-methoxyphenyl)-N-(4-fluorophenyl)aminomethylphosphonate(1036406-57-1)

Safety Data

• Hazardous Substances Data: 1036406-57-1(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 371-40-4 4-fluoroaniline 
• 122-52-1 triethyl phosphite 
• 78-40-0 triethyl phosphate 

Relevant articles and documents

SO3H-functionalized ionic liquids catalyzed the synthesis of α-aminophosphonates in aqueous media

SO3H-functionalized halogen-free ionic liquids were prepared and used as efficient and recyclable catalysts for the synthesis of α-aminophosphonates at room temperature via the one-pot three-component condensation reaction in aqueous media with good yields of 80-96%. The postprocessing was simple, and the catalysts could be reused at least six times without noticeably decreasing the catalytic activity.

A highly efficient bismuth salts-catalyzed route for the synthesis of α-aminophosphonates

A convenient synthesis of different types of α-amino phosphonates via one-pot solvent-free three component reactions of aldehydes, amines and phosphites catalyzed by bismuth salts has been investigated. Bismuth triflate is found to be the most effective catalyst for this reaction.

Supported sulfonic acid on magnetic nanoparticles used as a reusable catalyst for rapid synthesis of α-aminophosphonates

Sulfonic acid was anchored on the surface of silica-coated cobalt ferrite core to obtain a new magnetically separable catalyst. The resultant composite was characterized by various techniques, including FT-IR, X-ray diffraction, FESEM, energy-dispersive X-ray, TEM, TGA, and vibrating sample magnetometer. The immobilized sulfonic acid was shown to be an efficient heterogeneous catalyst for the synthesis of a-aminophosphonates under solvent-free conditions at room temperature. The catalyst is readily recovered by simple magnetic decantation and can be recycled 7 times with no significant loss of catalytic activity.

Clean procedure for the synthesis of A-aminophosphonates catalyzed by choline-based ionic liquid

A sulfated choline-based ionic liquid [Ch-OSO3H] was prepared and used as a novel catalyst for the synthesis of α-aminophosphonates via a one-pot three-component reaction with aldehydes, amines, and triethyl phosphite/diethyl phosphite at room temperature under solvent-free conditions or in aqueous media. The reaction was completed in short times and products could be simply separated from the reaction mixture in good to excellent yields. The catalyst could be recycled and reused for several times without noticeably reducing catalytic activity.

Magnetic nanoparticle supported polyoxometalate: An efficient and reusable catalyst for solvent-free synthesis of α-aminophosphonates

A new magnetically separable catalyst consisting of phosphotungstic acid (PTA) supported on imidazole functionalized silica coated cobalt ferrite nanoparticles was prepared. The synthesized catalyst was characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The immobilized phosphotungstic acid was shown to be an efficient heterogeneous catalyst for the synthesis of α-aminophosphonates under solvent-free conditions at room temperature. The catalyst is readily recovered by simple magnetic decantation and can be recycled several times with no significant loss of catalytic activity.

Catalyst and solvent-free, ultrasound promoted rapid protocol for the one-pot synthesis of α-aminophosphonates at room temperature

An ultrasound promoted easy, efficient, and environment friendly process has been devised for the synthesis of α-aminophosphonates within seconds through a one-pot three-component condensation of the aldehydes, amines, and triethylphosphite. The desired products were obtained in excellent yields and in high purity under solvent-free and catalyst-free conditions. Study with various aldehydes and amines reveals that ultrasound radiation plays a key role in the direct synthesis of α-aminophosphonates. 2012 Elsevier Ltd. All rights reserved.

Choline chloride·2ZnCl2 ionic liquid: An efficient and reusable catalyst for the solvent free Kabachnik-Fields reaction

The choline based Zn containing deep eutectic mixture was applied as an efficient and eco-friendly ionic liquid catalyst for the one pot three-component synthesis of α-aminophosphonates under solvent-free condition at room temperature. The reactions were completed in short times and products were obtained in good to excellent yields.

Silica supported polyphosphoric acid (PPA-SiO2): An efficient and reusable heterogeneous catalyst for the one-pot synthesis of α-amino phosphonates

An efficient green protocol is described for the preparation of α-amino phosphonates, employing a one-pot three-component condensation reaction between aldehydes, amines, and trialkyl phosphites in the presence of PPA-SiO2 under solvent-free conditions at 80 ° C. The present procedure offer advantages such as high to excellent yields, short reaction time, inexpensiveness, recovery, and reusability of catalyst. tuebitak.

TiO2 as a new and reusable catalyst for one-pot three-component syntheses of α-aminophosphonates in solvent-free conditions

Commercially available titania (TiO2) is reported as an extremely efficient catalyst for the synthesis of α-aminophosphonates. A three-component reaction of an amine, an aldehyde or a ketone and a dialkyl phosphite (Kabachnik-Fields reaction) took place in one-pot, under solvent-free conditions to afford the corresponding α-aminophosphonates in high yields and short times. The TiO2 catalyzed α-aminophosphonate synthesis in the present study perhaps represents a true three-component reaction as no intermediate formation of either an imine or α-hydroxyphosphonate was observed that indicated the simultaneous involvement of the carbonyl compound, the amine and the phosphite in the transition state. Furthermore, the catalyst can be reused for several times without any significant loss of catalytic activity.