1036588-32-5

Basic information

• Product Name: 4-Isopropoxy-3-Methoxybenzyl chloride
• Synonyms: 4-Isopropoxy-3-Methoxybenzyl chloride;4-(Chloromethyl)-1-isopropoxy-2-methoxybenzene;4-(Chloromethyl)-2-methoxy-1-(1-methylethoxy)benzene
• CAS NO: 1036588-32-5
• Molecular Formula: C₁₁H₁₅ClO₂
• Molecular Weight: 214.6886
• Mol File: 1036588-32-5.mol

Chemical Properties

• Boiling Point: 288.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.081±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Isopropoxy-3-Methoxybenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isopropoxy-3-Methoxybenzyl chloride(1036588-32-5)
• EPA Substance Registry System: 4-Isopropoxy-3-Methoxybenzyl chloride(1036588-32-5)

Safety Data

• Hazardous Substances Data: 1036588-32-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Isopropoxy-3-methoxybenzyl chloride is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the creation of complex molecules, making it a valuable component in organic chemistry.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-Isopropoxy-3-methoxybenzyl chloride is utilized as a precursor in the development of new drugs and pharmaceuticals. Its chemical properties enable the design of novel drug candidates with potential therapeutic applications.
Used in Material Science:
4-Isopropoxy-3-methoxybenzyl chloride is also employed in the field of material science for the development of new materials and chemical processes. Its versatility and reactivity contribute to the creation of innovative materials with unique properties and applications.
Used in Medicinal Chemistry:
In medicinal chemistry, 4-Isopropoxy-3-methoxybenzyl chloride is used as a building block for the design and creation of new drugs. Its presence in the molecular structure can influence the pharmacological properties of the resulting compounds, making it an essential component in drug discovery and development.

Upstream product

• 2539-22-2 vanillin 
• 2538-98-9 4-isopropyloxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 

Downstream Products

• 861069-45-6 vanillin 
• 97614-65-8 lamellarin D 
• 656836-79-2 14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 

Relevant articles and documents

Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents

Enlightened by the modification route from Camptothecin (CPT) to Topotecan and based on classical drug design theory, a series of Mannich derivatives of lamellarin D were designed and synthesized in 26-27 steps starting from vanillin and isovanilin. All synthesized compounds were then biologically evaluated for their in vitro anti-cancer activities and Topo I inhibitory activities. The results showed that most target compounds exhibited Topo I inhibitory activities in equivalent level with that of lamellarin D. Compound SL-9 exhibited better Topo I inhibitory activity than that of lamellarin D. Compounds SL-2, SL-3, SL-4, SL-5 and SL-11 exhibited better anti-proliferative activity against HT-29 cells than that of lamellarin D.

Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents

A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.