10374-27-3Relevant academic research and scientific papers
Stereoselective One-Pot Synthesis of Dihydropyrimido[2,1-a]isoindole-6(2H)-ones
Kramer, Philipp,Sch?nfeld, Julia,Bolte, Michael,Manolikakes, Georg
, p. 178 - 181 (2018)
A diastereoselective one-pot synthesis of highly substituted dihydropyrimido[2,1-a]isoindole-6(2H)-ones containing three continuous stereocenters is reported. The reaction sequence is based on a hetero-Diels-Alder reaction between an enimide and a N-acylimine followed by an unprecedented Br?nsted acid mediated rearrangement of an intermediate 5,6-dihydro-4H-1,3-oxazine to a pyrimido[2,1-a]isoindole.
