1037589-69-7Relevant academic research and scientific papers
Scalable and cost-effective synthesis of a linker for bioconjugation with a peptide and a monoclonal antibody
Magano, Javier,Conway, Brian G.,Farrand, Douglas,Lovdahl, Michael,Maloney, Mark T.,Pozzo, Mark J.,Teixeira, John J.,Rizzo, John,Tumelty, David
, p. 1399 - 1406 (2014/06/09)
An efficient, scalable, and cost-effective synthesis of a linker employed in a bioconjugation process with a peptide and a monoclonal antibody is presented. Several routes were investigated that resulted in the identification of a short synthesis to a key acid intermediate from inexpensive and readily available starting materials. The final coupling of this acid with an aniline to afford the desired linker has been optimized to produce multi-gram quantities of material for clinical studies. The very limited purifications needed for both intermediates and final product make this route amenable to scale. Georg Thieme Verlag Stuttgart New York.
Development of novel linkers to conjugate pharmacophores to a carrier antibody
Palanki, Moorthy S.S.,Bhat, Abhijit,Lappe, Rodney W.,Liu, Bin,Oates, Bryan,Rizzo, John,Stankovic, Nebojsa,Bradshaw, Curt
, p. 4249 - 4253 (2012/07/17)
We have developed modified maleimide novel linkers with improved chemical stability that could potentially be used in conjugating various pharmacophores such as oligo nucleotides, peptides, and proteins to antibodies to afford novel biologics with well-de
