1037746-97-6

Basic information

• Product Name: tert-butyl 2-phenylthiazole-4-carboxylate
• Synonyms: tert-butyl 2-phenylthiazole-4-carboxylate
• CAS NO: 1037746-97-6
• Molecular Weight: 261.345
• Mol File: 1037746-97-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-phenylthiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-phenylthiazole-4-carboxylate(1037746-97-6)
• EPA Substance Registry System: tert-butyl 2-phenylthiazole-4-carboxylate(1037746-97-6)

Safety Data

• Hazardous Substances Data: 1037746-97-6(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 1037746-91-0 tert-butyl 1,3-thiazole-4-carboxylate 
• 108-90-7 chlorobenzene 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 591-50-4 iodobenzene 

Relevant articles and documents

Ligand controlled orthogonal base-assisted direct C-H bond arylation in oxa(thia)zole-4-carboxylate series. New insights in nCMD mechanism

Alkyl- and arylphosphines have been screened in competitive C2-H/C5-H direct phenylation of oxa(thia)zole-4-carboxylates using Cs2CO 3 and Rb2CO3 carbonate bases. nCMD-based C2-H selective direct phenylation was

Direct C-2 arylation of alkyl 4-thiazolecarboxylates: New insights in synthesis of heterocyclic core of thiopeptide antibiotics

(Chemical Equation Presented) The Pd(0)-catalyzed regioselective C-2 (hetero)arylation of tert-butyl 4-thiazolecarboxylate with a broad (hetero)aryl halide is reported, including the direct coupling of pyridinyl halides. The process has allowed the preparation of valuable 2-pyridynyl-4- thiazolecarboxylates which are components of the complex heterocyclic core of thiopeptides antibiotics. As a first application, a synthesis of a tert-butyl sulfomycinamate thio-analogue from tert-butyl 4-thiazolecarboxylate is here described through a three-step direct pyridinylation, halogenation, and Stille cross-coupling sequence.