1037795-34-8

Upstream product

• 1037795-30-4 C₃₇H₄₅N₅O₇ 
• 13734-41-3 t-Boc-L-valine 
• 3392-12-9 Boc-Val-ONSu 
• 870487-08-4 (6S,9S)-1-amino-9-isopropyl-13,13-dimethyl-1,8,11-trioxo-12-oxa-2,7,10-triazatetradecane-6-carboxylic acid 
• 18144-47-3 tert-butyl 4-aminobenzoate 
• 1037794-82-3 C₁₇H₂₆N₄O₄ 
• 932744-52-0 C₃₂H₃₆N₄O₆ 
• 133174-15-9 (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-ureidopentanoic acid 

Downstream Products

• 1037795-38-2 C₃₄H₄₉N₇O₈ 
• 1037795-42-8 C₃₀H₄₁N₇O₈ 

Relevant academic research and scientific papers

MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE

Provided herein are maytansinoid derivatives, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.

CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF

The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.