10381-70-1

Basic information

• Product Name: 1-(benzylsulfinyl)-4-methylbenzene
• Synonyms: 1-(Benzylsulfinyl)-4-methylbenzene; benzene, 1-methyl-4-[(phenylmethyl)sulfinyl]-; Benzyl 4-methylphenyl sulfoxide; Benzyl(4-methylphenyl)sulfoniumolate; sulfonium, hydroxy(4-methylphenyl)(phenylmethyl)-, inner salt
• CAS NO: 10381-70-1
• Molecular Formula: C₁₄H₁₄OS
• Molecular Weight: 230.3254
• Mol File: 10381-70-1.mol

Chemical Properties

• Boiling Point: 405.4°C at 760 mmHg
• Flash Point: 199°C
• Density: 1.19g/cm³
• Vapor Pressure: 2.05E-06mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 1-(benzylsulfinyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzylsulfinyl)-4-methylbenzene(10381-70-1)
• EPA Substance Registry System: 1-(benzylsulfinyl)-4-methylbenzene(10381-70-1)

Safety Data

• Hazardous Substances Data: 10381-70-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(benzylsulfinyl)-4-methylbenzene is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for further functionalization and modification, making it a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(benzylsulfinyl)-4-methylbenzene is used as a starting material or a key intermediate in the development of new drugs. Its reactivity and structural features can be exploited to design and synthesize novel bioactive compounds with potential therapeutic applications.
It is important to handle 1-(benzylsulfinyl)-4-methylbenzene with caution, as it may have potential hazards and safety concerns associated with its use. Proper safety measures should be taken during its handling, storage, and disposal to minimize any risks.

Upstream product

• 536-57-2 p-toluene sulfinic acid 
• 60-29-7 diethyl ether 
• 5023-60-9 1-benzylsulfanyl-4-methyl-benzene 
• 1774-35-2 di(p-tolyl) sulfoxide 
• 1121-53-5 benzyl sodium 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 1589-82-8 phenylmagnesium bromide 
• 108-88-3 toluene 
• 6921-34-2 benzylmagnesium chloride 
• 1858-86-2 Ethyl p-toluenesulfinate 
• 106474-26-4 N-(toluene-4-sulfinyloxy)-phthalimide 
• 921765-53-9 3-(phenylmethylsulfinyl)propionic acid tert-butyl ester 
• 624-31-7 4-tolyl iodide 
• 1517-82-4 (-)-menthyl p-toluenesulfinate 

Downstream Products

• 5023-60-9 1-benzylsulfanyl-4-methyl-benzene 
• 304690-05-9 benzyl p-tolyl sulfoxide 
• 4820-08-0 (R)-1-(benzylsulfinyl)-4-methylbenzene 
• 5395-20-0 1-methyl-4-(benzylsulfonyl)benzene 
• 77096-69-6 1-benzenesulfinyl-4-methyl-benzene 
• 588-46-5 N-(phenylmethyl)acetamide 
• 100907-35-5 (R)-2-Methylene-4-phenyl-4-((R)-toluene-4-sulfinyl)-butyric acid 
• 100907-25-3 (S)-2-Methylene-4-phenyl-4-((R)-toluene-4-sulfinyl)-butyric acid 
• 104891-17-0 (R)-3-Bromo-1-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-one 
• 104891-20-5 (S)-3-Bromo-1-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-one 
• 115879-08-8 (3R,R_S)-1-fluoro-3-<(4-methylphenyl)sulfinyl>-3-phenylpropan-2-one 
• 115879-11-3 (3S,R_S)-1-fluoro-3-<(4-methylphenyl)sulfinyl>-3-phenylpropan-2-one 
• 184636-31-5 (R)-2-Ethoxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester 
• 184636-30-4 (S)-2-Ethoxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester 

Relevant articles and documents

Cyanuric chloride promoted oxidation of sulfides to sulfoxides or sulfones in the presence of hydrogen peroxide

Aromatic and aliphatic sulfides are readily oxidized to sulfoxides or sulfones in high yield with 35% hydrogen peroxide in the presence of cyanuric chloride (CC) as an efficient activator. The oxidation of sulfides proceeds at room temperature and the corresponding sulfoxides or sulfones was selectively obtained by controlling the amounts of H2O2 and CC. Various sulfides possessing functional groups such as hydroxyl, methoxy, nitrile, aldehyde and olefinic double bond were successfully and selectively oxidized without affecting sensitive functionalities. [image omitted].

Ion exchange resin catalyzed selective oxidation of sulfides to sulfoxides using hydrogen peroxide

An efficient method for the selective oxidation of sulfides to sulfoxides under mild and environmentally safe conditions is achieved using hydrogen peroxide in the presence of Amberlyst 15 and Amberlite IR-400 at room temperature. This procedure can be ap

Selective oxidation of sulfides to sulfoxides catalysed by deep eutectic solvent with H2O2

A Bronsted acidic deep eutectic solvent based on choline chloride and p-toluenesulfonic acid (ChCl/p-TsOH, 1 : 1) was prepared and utilised for the selective oxidation of sulfides with H2O2 as the oxidant. Broad substrate compatibili

Alanine/chlorochromic acid/silica gel: An efficient and selective reagent for the oxidation of organic functional groups

Alanine / chlorochromic acid / silica gel is a new and selective reagent for the efficient oxidation of sulfides, thiols, oximes, and alcohols. Oxidation of sulfides is solvent dependent. In chloroform at room temperature sulfoxides are formed as the major products, while in carbon tetrachloride or under solvent-free conditions solfones are produced in good-to-excellent yields.

A multifunctional Co-based metal-organic framework: heterogeneous catalysis, chemiluminescence sensing and moisture-dependent solvatochromism

Crystalline materials with multi-catalytic applications are of great value to both fundamental research and practical applications. The platform of metal-organic frameworks (MOFs) is utilized to fabricate a microporous versatile catalyst with high stability. Self-assembly of a flexible ligand, 4-(4-carboxybenzylamino)benzoic acid (H2CBBA), with Co(ii) resulted in a 3D framework, CBBA-Co, with Co3O clusters exposed in the zigzag channels. Upon in situ activation, CBBA-Co exhibited multiple heterogeneous catalytic activities. Theoretical calculations were carried out to give insights into the catalytic process. In addition, CBBA-Co also showed promising potential in optical sensing by virtue of its catalytic activity. The luminol chemiluminescence was greatly enhanced by CBBA-Co, and linear determination of the concentration of H2O2 in the range of 0-30% was established. The successful implementation of CBBA-Co indicates the feasibility and promising future of employing MOFs as an efficient platform for the fabrication and study of multifunctional catalysts, both experimentally and theoretically.

Magnetic core-shell nanoparticle-supported Sc (III): A novel and robust Lewis acid nanocatalyst for the selective oxidation of sulfides to sulfoxides by H2O2 under solvent-free conditions

For the first time scandium triflate was supported on modified Fe3O4 magnetic nanoparticles [MNPs-PhSO3-Sc(OTf)2] and characterized using scanning electron microscopy (SEM), inductively coupled plasma analysis (

Tungstate-exchanged Mg-Al-LDH catalyst: An eco-compatible route for the oxidation of sulfides in aqueous medium

The catalytic oxidation of sulfides selectively to sulfoxides and/or sulfones is realised for the first time with heterogeneous tungstate-exchanged Mg-Al-LDH catalyst using 30% hydrogen peroxide in aqueous media at a faster rate in quantitative yields at room temperature. The heterogeneous catalyst showed higher activity (TOF) over its homogeneous analogues and other heterogeneous catalysts reported so far. The catalyst is well characterised by various instrumental techniques such as FT-IR spectroscopy, thermal analysis (TGA and DTA), powder XRD and chemical analysis. The catalyst is reused for six cycles with consistent activity and selectivity.

A SnIV-porphyrin-based metal-organic framework for the selective photo-oxygenation of phenol and sulfides

A functional tin(IV)-porphyrin derivative was used as a building block to construct a novel 3D porous metal-organic framework (MOF). The MOF is built up from tin(IV)-porphyrin struts linking up Zn atoms and formates joining Sn IV centers. The i

Efficient and highly selective aqueous oxidation of sulfides to sulfoxides at room temperature catalysed by supported iron oxide nanoparticles on SBA-15

The present manuscript describes a simple, efficient and environmentally friendly room temperature aqueous catalytic approach to the selective preparation of sulfoxides from sulfides utilising low-loaded supported iron oxide nanoparticles and aqueous hydr

EFFICENT OXIDATION OF SULFIDES TO THE SULFOXIDES USING A NEW SULFINYLPEROXY INTERMEDIATE GENERATED FROM 2-NITROBENZENESULFINYL CHLORIDE AND SUPEROXIDE

Various sulfides were found to react with a sulfinylperoxy intermediate generated in situ by the treatment of 2-nitrobenzenesulfinyl chloride with superoxide at -25 deg C in acetonitrile to afford the corresponding sulfoxides selectively in excellent yields together with traceable amount of the sulfones under mild conditions.