103962-17-0Relevant articles and documents
Alpha-aminoamide derivative and application thereof
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Paragraph 0264; 0266; 0267, (2019/02/04)
The invention discloses an alpha-aminoamide derivative and application thereof. Specifically, the invention relates to a novel alpha-aminoamide derivative and a pharmaceutical composition containing the compound. The invention also relates to a method for
Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
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Page 305; 349, (2010/02/10)
This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
Triazole antifungal agent
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, (2008/06/13)
A triazole compound having the formula: STR1 wherein Ar1 represents an optionally substituted phenyl, Ar2 represents an optionally substituted phenyl, R0 represents a hydrogen atom or a lower alkyl; R1 represents a lower alkyl; R2 to R5 represent a hydrogen atom or an unsubstituted or halo substituted alkyl, n represents 0 to 2; p represents 0 or 1; q, r and s each represent 0 to 2; and A represents a 1,3-dioxan-5-yl. The triazole compound of the present invention exhibits an excellent antifungal activity.