1039733-30-6

Upstream product

• 1039735-65-3 N-[4-[[(2-chloroquinazolin-4-yl)amino]methyl]phenyl]-4-fluorobenzamide 
• 124-40-3 dimethyl amine 
• 403-43-0 4-fluorobenzoyl chloride 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 
• 926207-17-2 N-[4-(aminomethyl)phenyl]-4-fluorobenzamide 
• 607-68-1 2,4-dichloroquinazoline 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors

More than 50 new diaminoquinazoline derivatives have been synthesized and evaluated in a colon carcinoma cell growth inhibition assay using HCT116 and SW480 cells. Twenty compounds with good cell growth inhibitory activities (50 values 50 values of 1.5-2.5 μM for HCT116 cells with the luciferase reporter assay.

AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS

The present invention relates to amino-substituted quinazoline derivatives as inhibitors of β-catenin/tcf-4 pathway, which can be useful in the treatment of cancer; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.