4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

Base Information

Chemical Name:4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide
CAS No.:1039733-30-6
Molecular Formula:C₂₄H₂₂FN₅O
Molecular Weight:415.47
Hs Code.:

Synonyms:4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

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Chemical Property of 4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

Chemical Property:

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Technology Process of 4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

There total 5 articles about 4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1039735-65-3
N-[4-[[(2-chloroquinazolin-4-yl)amino]methyl]phenyl]-4-fluorobenzamide

: 124-40-3
dimethyl amine

: 1039733-30-6
4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

Guidance literature:: With water; In tetrahydrofuran; at 100 ℃; for 21h;

Reference yield:

: C₁₉H₂₁FN₂O₃

: 1039733-30-6
4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: triethylamine / tetrahydrofuran; dichloromethane / 20 °C

3: 100 - 120 °C / Sealed tube

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201494a

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1039733-30-6
4-fluoro-N-[4-[[(2-(dimethylamino)quinazolin-4-yl)amino]methyl]phenyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 4 h / 20 °C / Cooling with ice; Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

3: triethylamine / tetrahydrofuran; dichloromethane / 20 °C

4: 100 - 120 °C / Sealed tube

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201494a