103976-52-9Relevant academic research and scientific papers
HYDROXYL PURINE COMPOUNDS AND USE THEREOF
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Paragraph 0528; 0530, (2018/04/05)
Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.
HYDROXYL PURINE COMPOUNDS AND USE THEREOF
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Paragraph 0267; 0269, (2018/06/09)
Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof.
Imination of N-Methylazinium Salts by Liquid Ammonia/Potassium Permanganate
Wozniak, M.,Buurman, D.J.,Plas, H.C. van der
, p. 765 - 769 (2007/10/02)
Treatment of 1-methylquinolinium-, 1,4-dimethylquinolinium- and 1-methyl-1,X-naphthyridinium iodides (X=5,8) with liquid ammonia/potassium permanganate leads to introduction of the imino group at C-2 forming the 1,2-dihydro-2-imino-1-methylquinolines and 1,2-dihydro-2-imino-1-methyl-1,X-naphthyridines (X=5,8) respectively. 1,2-Dimethylquinolinium iodide, when subjected to treatment with liquid ammonia/potassium permanganate undergoes an oxo-demethylation reaction, yielding 1-methylquinol-2-one.The nmr-measurements of solutions of the above-mentioned salts in liquid ammonia clearly show the formation of ?-adduct, strongly suggesting that these ?-adducts are intermediates in the imination reactions.
