98106-29-7

Upstream product

• 110-91-8 morpholine 
• 98105-79-4 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 86483-51-4 ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate 
• 98105-80-7 1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester 
• 98105-65-8 ethyl 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxobenzenepropanoate 
• 103994-99-6 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 
• 86483-52-5 2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 

Relevant academic research and scientific papers

Synthesis of norfloxacin analogues catalyzed by Lewis and Br?nsted acids: An alternative pathway

An alternative synthetic pathway to prepare norfloxacin analogues is presented. Three Lewis acids (CeCl3·7H2O, AlCl 3·6H2O, ZnCl2) and one Bro?nsted acid (TsOH) were tested as catalysts in the prepara

Synthesis and Structure-Activity Relationships of Novel Arylfluoroquinolone Antibacterial Agents

A series of novel arylfluoroquinolones has been prepared.These derivatives are characterized by having a fluorine atom at the 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.Structure-activity relationship (SAR) studies indicate that the in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or p-hydroxyphenyl and the 7-substituent is either 1-piperazinyl, 4-methyl-1-piperazinyl, or 3-amino-1-pyrrolidinyl.The electronic and spatial properties of the 1-substituent, as well as the steric bulk, play important roles in the antimicrobial potency in this class of antibacterials.As a result of this study, compounds 45 and 41 were found to possess excellent in vitro potency and in vivo efficacy.