1040402-96-7Relevant academic research and scientific papers
A new mathematical method for determining the enantiomeric ratio in lipase-catalyzed reactions
Mitchell, David Alexander,Moure, Vivian Rotuno,Marques, Francisco de Assis,Krieger, Nadia
experimental part, p. 23 - 28 (2010/11/02)
We present a new mathematical method for determining the enantiomeric ratio (E) during lipase-catalyzed kinetic resolutions. The method involves the fitting of a model to profiles of adimensionalized concentrations of the two enantiomers of the chiral substrate, plotted against degree of conversion. The model equations are presented for a reversible reaction involving bi-bi ping-pong kinetics in which the chiral substrate enters second and the chiral product leaves second. However, it is also shown that the method is easy to modify for analysis of resolutions involving other chiral substrate-product pairs and of resolutions in which the behavior of the system can be approximated by irreversible uni-uni kinetics. We show that our method retains several advantageous features of existing methods that help to ensure accuracy.
Enantioselective hydrolysis of 1-arylallyl acetates catalyzed by Candida antarctica lipase
Kadnikova, Ekaterina N.,Thakor, Vikalp A.
, p. 1053 - 1058 (2008/09/19)
(R)-1-Arylallyl alcohols were obtained with excellent enantioselectivities via kinetic resolution of the corresponding acetates using immobilized Candida antarctica lipase. The scope and limitations of this reaction were investigated. The best results are obtained using the water/acetonitrile solvent system, and the reaction tolerates a variety of aryl and heteroaryl substituents.
