10408-91-0

Basic information

• Product Name: N-INDAN-1-YL-ACETAMIDE
• Synonyms: N-INDAN-1-YL-ACETAMIDE
• CAS NO: 10408-91-0
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 10408-91-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 372.3 °C at 760 mmHg
• Flash Point: 220.1 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 9.72E-06mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: N-INDAN-1-YL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-INDAN-1-YL-ACETAMIDE(10408-91-0)
• EPA Substance Registry System: N-INDAN-1-YL-ACETAMIDE(10408-91-0)

Safety Data

• Hazardous Substances Data: 10408-91-0(Hazardous Substances Data)

Usage

General Description

N-Indan-1-yl-acetamide is a chemical compound with the formula C11H13NO. It is classified as an acetamide, a type of organic compound that contains an amide group attached to a carbonyl carbon atom. N-Indan-1-yl-acetamide is derived from indan, a bicyclic hydrocarbon, and has potential applications in pharmaceutical and agricultural industries. It may be used as a building block in the synthesis of various organic compounds, and its pharmacological properties are currently under investigation. As a result, N-Indan-1-yl-acetamide is of interest to researchers and chemists for its potential use in drug development and other fields.

InChI:InChI=1/C11H13NO/c1-8(13)12-11-7-6-9-4-2-3-5-10(9)11/h2-5,11H,6-7H2,1H3,(H,12,13)

Upstream product

• 496-11-7 INDANE 
• 75-05-8 acetonitrile 
• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 75-36-5 acetyl chloride 
• 95-13-6 1-indene 
• 68253-35-0 indan-1-one oxime 
• 108-24-7 acetic anhydride 
• 70146-15-5 2,3-dihydro-1H-inden-1-amine hydrochloride 
• 592-20-1 Acetol acetate 
• 591-87-7 Allyl acetate 

Relevant articles and documents

C-H Amination via Electrophotocatalytic Ritter-Type Reaction

A method for C-H bond amination via an electrophotocatalytic Ritter-Type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C-H bonds to acetamides without the use of a stoichiometric chemical oxidant. A range of functionality is shown to be compatible with this transformation, and several complex substrates are demonstrated.

Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties

A series of aromatic sulfonamides incorporating indane moieties were prepared starting from commercially available 1- and 2-indanamine, and their activity as inhibitors of two carbonic anhydrase (CA, EC 4.2.1.1) isozymes, hCA I and II was studied. The new sulfonamides incorporating acetamido, 4-chloro-benzoyl, valproyl, tetra-, and pentafluorobenzoyl moieties acted as very potent inhibitors of the slow red blood cell isozyme hCA I (Kis in the range of 1.6-8.5 nM), which usually has a lower affinity for such inhibitors, as compared to isozyme II. Some derivatives also showed excellent hCA II inhibitory properties (Kis in the range of 2.3-12 nM), but the anticonvulsant activity of these sulfonamides was rather low as compared to that of other sulfonamide/sulfamate CA inhibitors, such as methazolamide. Furthermore, the 2-amino/acetamido-indane-5-sulfonic acids prepared during this work also showed interesting CA inhibitory properties, with inhibition constants in the range of 43-89 nM against the two isozymes, being among the most potent sulfonic acid CA inhibitors reported so far.

Manganese(III) acetate catalyzed oxidative amination of benzylic C(sp3)-H bonds with nitriles

Mn-Catalyzed oxidative amination of benzylic C(sp3)-H bonds with nitriles is disclosed, which enables the synthesis of a broad range of secondary amides in moderate to excellent yields under mild conditions. The interaction between Mn(iii) and DDQ facilitates the oxidation and makes it highly efficient and selective.

HBF4·OEt2 as a mild and versatile reagent for the Ritter amidation of olefins: A facile synthesis of secondary amides

A variety of alkenes undergo smooth amidation with nitriles in the presence of HBF4·OEt2 at room temperature under mild conditions to afford the corresponding secondary amides in good to excellent yields. This is a highly efficient method for the preparation of α-aryl ethyl amides especially from vinyl arenes without any side reactions such as olefin polymerization. The use of readily available and easy to handle reagent HBF4·OEt2 makes this method simple, convenient, and practical.