1041423-26-0

Basic information

• Product Name: 1,3-Dichloro-6-fluoroisoquinoline
• Synonyms: 1,3-Dichloro-6-fluoroisoquinoline;1,3-Dichloro-6-fluoroisoquinoline 97%
• CAS NO: 1041423-26-0
• Molecular Formula: C9H4Cl2FN
• Molecular Weight: 216.0391632
• Product Categories: Heterocyclic Building BlocksHeterocyclic Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Isoquinolines;New Products for Chemical Synthesis
• Mol File: 1041423-26-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 131-133 °C
• Boiling Point: 332.3 °C at 760 mmHg
• Flash Point: 154.7 °C
• Appearance: /
• Density: 1.491 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1,3-Dichloro-6-fluoroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dichloro-6-fluoroisoquinoline(1041423-26-0)
• EPA Substance Registry System: 1,3-Dichloro-6-fluoroisoquinoline(1041423-26-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 1041423-26-0(Hazardous Substances Data)

Usage

General Description

1,3-Dichloro-6-fluoroisoquinoline is a synthetic compound with the molecular formula C9H5Cl2FN. It is categorized as an isoquinoline derivative and contains a fluorine atom and two chlorine atoms. This chemical is primarily used in the pharmaceutical industry for the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential medicinal and biological properties, particularly in the treatment of infections and cancer. However, it should be handled with caution due to its potential hazards to human health and the environment. Overall, 1,3-Dichloro-6-fluoroisoquinoline is a versatile chemical with potential applications in various industries.

Upstream product

• 700-84-5 5-fluoro-1-indanone 
• 162751-93-1 (E)-5-fluoro-2-(hydroxyimino)-2,3-dihydroinden-1-one 

Downstream Products

• 1041423-28-2 3-chloro-6-fluoroisoquinoline 
• 1446192-30-8 3-chloro-6-fluoro-1-methylisoquinoline 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique opportuni

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES

The invention relates to 6-substituted isoquinoline derivatives of the Formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.