1041423-28-2

Basic information

• Product Name: 3-Chloro-6-fluoro-isoquinoline
• Synonyms: 3-Chloro-6-fluoro-isoquinoline;Isoquinoline, 3-chloro-6-fluoro-
• CAS NO: 1041423-28-2
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.5941032
• Mol File: 1041423-28-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Chloro-6-fluoro-isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-6-fluoro-isoquinoline(1041423-28-2)
• EPA Substance Registry System: 3-Chloro-6-fluoro-isoquinoline(1041423-28-2)

Safety Data

• Hazardous Substances Data: 1041423-28-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-6-fluoro-isoquinoline is used as a key intermediate in the development of new drugs, leveraging its unique structural features to enhance the properties of medicinal compounds. Its presence in drug molecules can contribute to improved pharmacokinetics, potency, and selectivity, making it an essential component in the advancement of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-6-fluoro-isoquinoline serves as a building block for the creation of innovative crop protection products. Its incorporation into agrochemical formulations can lead to the development of more effective and targeted pest control solutions, thereby enhancing crop yields and food security.
Used in Organic Synthesis:
3-Chloro-6-fluoro-isoquinoline is utilized as a versatile building block in organic synthesis, enabling the production of a wide range of chemical compounds. Its reactivity and structural diversity make it an invaluable tool for chemists in the synthesis of complex organic molecules for various applications, including pharmaceuticals, materials science, and specialty chemicals.
Used in Research and Development:
3-Chloro-6-fluoro-isoquinoline holds significant potential for use in research and development across multiple fields of science and technology. Its unique properties and reactivity make it a valuable subject for exploration in academic and industrial research settings, where it can contribute to the discovery of new chemical reactions, materials, and applications.

Upstream product

• 162751-93-1 (E)-5-fluoro-2-(hydroxyimino)-2,3-dihydroinden-1-one 
• 700-84-5 5-fluoro-1-indanone 
• 1041423-26-0 1,3-dichloro-6-fluoroisoquinoline 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique opportuni

PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES

Pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts are disclosed, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha- synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, the compounds are used as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. Futher, the compounds are useful for measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES

The invention relates to 6-substituted isoquinoline derivatives of the Formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE

The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I); useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.