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10420-75-4

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10420-75-4 Usage

Description

4'-chloroflavone, a flavonoid derivative with the molecular formula C15H9ClO2, is characterized by a chlorine substituent at the 4' position on the B-ring. This chemical compound has garnered attention for its potential anti-inflammatory and anti-cancer properties, making it a subject of ongoing research for its therapeutic applications in various diseases.

Uses

Used in Pharmaceutical Industry:
4'-chloroflavone is used as an anti-inflammatory agent for its ability to inhibit the production of inflammatory mediators and cytokines, which may contribute to the treatment of inflammatory diseases.
Used in Oncology:
4'-chloroflavone is used as an anti-cancer agent due to its antiproliferative effects on cancer cells. It induces apoptosis and cell cycle arrest, which can potentially lead to the development of new therapeutic strategies for cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 10420-75-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,2 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10420-75:
(7*1)+(6*0)+(5*4)+(4*2)+(3*0)+(2*7)+(1*5)=54
54 % 10 = 4
So 10420-75-4 is a valid CAS Registry Number.

10420-75-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-chlorophenyl)chromen-4-one

1.2 Other means of identification

Product number -
Other names 4'-Chloroflavone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10420-75-4 SDS

10420-75-4Relevant articles and documents

A 'one pot' synthesis of 2-aryl-4H-1-benzopyran-4-ones under coupled microwave phase transfer catalysis (PTC) and ultrasonic irradiation PTC

Pathak, Vijai N.,Gupta, Ragini,Varshney, Bindu

, p. 589 - 592 (2008)

(Chemical Equation Presented) A 'one pot' synthesis of 2-aryl-4H-1- benzopyran-4-ones (3a-3f) is being reported. A mixture of o-hydroxyacetophenone, aroyl chloride, powdered n-tetrabutylammonium hydrogensulphate (n-TBAHSO 4) and potassium hydroxide (KOH) were either irradiated by microwaves or sonicated in an ultrasonic cleaning bath to afford flavones directly. On the contrary, conventional liquid-liquid Phase Transfer Catalysis (PTC) using benzene as organic phase and aqueous KOH as the second phase afforded first β-diketones in accordance with Baker-Venkataraman synthesis which upon cyclization by p-toluenesulphonic acid (p-TSA) gave desired flavones in the next step. PTC coupled with microwaves or ultrasound show enhanced yields, the clean reaction conditions require less time, and have easier workup protocol. All synthesized compounds were characterized by their Proton Magnetic Resonance (PMR), IR, FAB Mass and elemental analyses.

A facile synthesis of flavones catalysed by gallium(III) triflate

Jin, Can,He, Fei,Wu, Huayue,Chen, Jiuxi,Su, Weike

, p. 27 - 29 (2009)

Ga(OTf)3 was explored as a novel catalyst for the cyclisation of 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones in nitromethane to flavones with excellent yields.

Ultrasonic-assisted synthesis of flavones by oxidative cyclization of 2′-hydroxychalcones using iodine monochloride

Lahyani, Achraf,Trabelsi, Mahmoud

, p. 626 - 630 (2016)

This paper presents an efficient methodology for the synthesis of flavones via the oxidative cyclization of 2′-hydroxychalcones in the presence of iodine monochloride with DMSO under ultrasound irradiation. Ultrasonic irradiation enhances the cyclization reaction and leads to reduced reaction time at lower reaction temperatures while generating flavones with high yields.

Cyclization of 2'-hydroxychalcones to flavones using ammonium iodide as an iodine source - An eco-friendly approach

Kulkarni, Pramod S.,Kondhare, Dasharath D.,Varala, Ravi,Zubaidha, Pudukulathan K.

, p. 909 - 916 (2013)

Ammonium iodide on exposure to air decomposes to ammonia and iodine. The in situ generated iodine was used for the cyclization of 2'-hydroxychalcones to the corresponding flavones under solvent-free conditions in good to excellent yields. This method could serve as an attractive alternative to the existing methods for synthesis of flavones and the use of toxic molecular iodine is avoided. Copyright

Syntheses of flavones via the iodine-mediated oxidative cyclization of 1,3-diphenylprop-2-en-1-ones

Miyake, Hideyoshi,Takizawa, Eizo,Sasaki, Mitsuru

, p. 835 - 836 (2003)

The syntheses of flavones from 1,3-diphenylporp-2-ene-1-ones are described. When 1,3-diphenylprop-2-en-1-ones were heated with iodine in triethylene glycol, oxidative cyclization underwent to obtain flavones in good yields.

A Facile Preparation of Flavones Using Nonaqueous Cation-Exchange Resin

Hoshino, Yukio,Takeno, Noboru

, p. 1919 - 1920 (1987)

Flavone was prepared from 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione by using nonaqueous cation exchange resin in a nearly quantitative yield.Of several reaction media, isopropyl alcohol gave the best result.Eight substituted flavones were also synthesized from the corresponding diketones in satisfactory yields.

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Son, Seung Hwan,Cho, Yang Yil,Yoo, Hyung-Seok,Lee, Soo Jin,Kim, Young Min,Jang, Hyu Jeong,Kim, Dong Hwan,Shin, Jeong-Won,Kim, Nam-Jung

, p. 14000 - 14006 (2021/04/22)

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

CF3SOCl-promoted intramolecular cyclization of β-diketones: An efficient synthesis of flavones

Sun, Dong-Wei,Zhou, Yong-Yan,Jiang, Min,Nian, Tang,Liu, Jin-Tao

, (2021/05/31)

An efficient intramolecular cyclization reaction of β-diketones containing a phenyl group with an ortho-hydroxyl substituent was achieved. Using CF3SOCl as an additive, the reaction took place under transition-metal-free and mild conditions. A series of flavones were synthesized in moderate to excellent yields.

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