10421-76-8

Basic information

• Product Name: noscapine
• Synonyms: noscapine
• CAS NO: 10421-76-8
• Molecular Weight: 413.427
• Mol File: 10421-76-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: noscapine(CAS DataBase Reference)
• NIST Chemistry Reference: noscapine(10421-76-8)
• EPA Substance Registry System: noscapine(10421-76-8)

Safety Data

• Hazardous Substances Data: 10421-76-8(Hazardous Substances Data)

Upstream product

• 35933-62-1 1S,9S β-narcotine 
• 3860-46-6 1R,9R-(-)-β-narcotine 
• 519-05-1 opianic acid 
• 62059-59-0 methyl 6-formyl-2,3-dimethoxybenzoate 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 
• 36017-64-8 (±)-β-N-demethyl noscapine 
• 5438-36-8 5-iodovaniline 
• 3934-87-0 5-hydroxyvanillin 
• 108460-85-1 amino>acetaldehyde dimethyl acetal 
• 108261-02-5 -N-methylamino>acetaldehyde dimethyl acetal 
• 108261-07-0 5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo<4,5-g>isoquinolin-8-ol 
• 550-10-7 hydrocotarnine 
• 30936-27-7 4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide 

Downstream Products

• 569-31-3 meconin 
• 131-28-2 Narcein 
• 518-90-1 3,4-dimethoxy-phthalic acid 
• 82-54-2 4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-ol 
• 519-05-1 opianic acid 
• 483-89-6 2,3-dimethoxy-6-{[4-methoxy-6-(2-methylamino-ethyl)-benzo[1,3]dioxol-5-yl]-acetyl}-benzoic acid 
• 106424-06-0 C-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-C,C'-(3,4-dimethoxy-o-phenylene)-bis-methanol 
• 54383-36-7 α-narcotine N-oxide 
• 64-19-7 acetic acid 
• 115940-16-4 narcotine N-oxide 
• 64816-77-9 {2-[6-(3,4-dimethoxy-2-methoxycarbonyl-phenacyl)-7-methoxy-benzo[1,3]dioxol-5-yl]-ethyl}-trimethyl-ammonium; iodide 
• 69937-26-4 (3,4-dimethoxy-2-methyl-phenyl)-(4-methoxy-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-methanone 
• 550-10-7 hydrocotarnine 

Relevant articles and documents

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A new total synthesis of (±)-α-noscapine

A new, convergent total synthesis of (±)-α-noscapine was developed on a grams scale through the condensation of 3-trimethylsilyl-meconin derivative 9 and the iodized salt cotarnine derivative 20 as the key step. Staring from simple 2,3-dimethoxybenzoic acid, piperonal and 2,2-dimethoxyethanamine, through the traditional chemical processes to give the final product in 11.6% yield over 14 steps.

NARCOTINE PURIFICATION PROCESS

A process for purifying Narcotine to remove color and impurities to form Noscapine. The process includes forming an aqueous isopropanol solution with the Narcotine product wherein the isopropanol concentration of the solution is about 20% to about 70% by volume; and adjusting the pH of the solution with a strong base to a pH of about 10 to about 14, wherein impurities are removed from the Narcotine product.