104354-37-2Relevant academic research and scientific papers
One-pot synthesis of oxime ethers from benzaldehyde or acetophenone, hydroxylamine salt, potassium hydroxide, and alkyl halides
Li, Chunbao,Zhang, Hang,Cui, Yi,Zhang, Shuanming,Zhao, Zheyuan,Choi, Michael C. K.,Chan, Albert S. C.
, p. 543 - 546 (2007/10/03)
Oxime ethers were synthesized in one-pot reaction from benzaldehyde or acetophenone, hydroxylamine hydrogen chloride, alkyl halides and KOH in aqueous DMSO. The reactions were completed in 15-50 min with yields in 80-96%.
Asymmetric Synthesis Using Chirally Modified Borohydrides. Part 3. Enantioselective Reduction of Ketones and Oxime Ethers with Reagents Prepared from Borane and Chiral Amino Alcohols
Itsuno, Shinichi,Nakano, Michio,Miyazaki, Koji,Masuda, Hirofumi,Ito, Koichi,et al.
, p. 2039 - 2044 (2007/10/02)
The asymmetric reduction of aromatic and aliphatic ketones, halogeno ketones, keto esters, and ketone oxime ethers with reagents prepared from borane and chiral amino alcohols has been investigated.When α,α-diphenyl-β-amino alcohols, such as (2S,3R)-(-)-2-amino-3-methyl-1,1-diphenylpentanol (2d), were used as a chiral auxiliary, very high enantioselectivities (ca. 90percent e.e.) were obtained in the reduction of various ketones and oxime ethers.
